Projekteja vuodessa
Abstrakti
Brain-on-Chip devices, which facilitate on-chip cultures of neurons to simulate brain functions, are receiving tremendous attention from both fundamental and clinical research. Consequently, microsensors are being developed to accomplish real-time monitoring of neurotransmitters, which are the benchmarks for neuron network operation. Among these, electrochemical sensors have emerged as promising candidates for detecting a critical neurotransmitter, dopamine. However, current state-of-the-art electrochemical dopamine sensors are suffering from issues like limited sensitivity and cumbersome fabrication. Here, a novel route in monolithically microfabricating vertically aligned carbon nanofiber electrochemical dopamine microsensors is reported with an anti-blistering slow cooling process. Thanks to the microfabrication process, microsensors is created with complete insulation and large surface areas. The champion device shows extremely high sensitivity of 4.52× 104 µAµM−1·cm−2, which is two-orders-of-magnitude higher than current devices, and a highly competitive limit of detection of 0.243 nM. These remarkable figures-of-merit will open new windows for applications such as electrochemical recording from a single neuron.
Alkuperäiskieli | Englanti |
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Artikkeli | 2303872 |
Sivumäärä | 12 |
Julkaisu | Advanced Healthcare Materials |
Vuosikerta | 13 |
Numero | 18 |
Varhainen verkossa julkaisun päivämäärä | 5 kesäk. 2024 |
DOI - pysyväislinkit | |
Tila | Julkaistu - 17 heinäk. 2024 |
OKM-julkaisutyyppi | A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä |
Sormenjälki
Sukella tutkimusaiheisiin 'Ultrasensitive Monolithic Dopamine Microsensors Employing Vertically Aligned Carbon Nanofibers'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.Projektit
- 1 Päättynyt
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CONNECT: Connecting neural networks: Nervous-system-on-Chip Technology
01/12/2018 → 30/06/2024
Projekti: EU: Framework programmes funding
Laitteet
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OtaNano Nanomikroskopiakeskus
Jani Seitsonen (Manager) & Anna Rissanen (Other)
OtaNanoLaitteistot/tilat: Facility