Ultrasensitive Monolithic Dopamine Microsensors Employing Vertically Aligned Carbon Nanofibers

Lingju Meng*, Maedeh Akhoundian, Anas Al Azawi, Yalda Shoja, Pei-Yin Chi, Kristoffer Meinander, Sami Suihkonen, Sami Franssila*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

1 Sitaatiot (Scopus)
11 Lataukset (Pure)

Abstrakti

Brain-on-Chip devices, which facilitate on-chip cultures of neurons to simulate brain functions, are receiving tremendous attention from both fundamental and clinical research. Consequently, microsensors are being developed to accomplish real-time monitoring of neurotransmitters, which are the benchmarks for neuron network operation. Among these, electrochemical sensors have emerged as promising candidates for detecting a critical neurotransmitter, dopamine. However, current state-of-the-art electrochemical dopamine sensors are suffering from issues like limited sensitivity and cumbersome fabrication. Here, a novel route in monolithically microfabricating vertically aligned carbon nanofiber electrochemical dopamine microsensors is reported with an anti-blistering slow cooling process. Thanks to the microfabrication process, microsensors is created with complete insulation and large surface areas. The champion device shows extremely high sensitivity of 4.52× 104 µAµM−1·cm−2, which is two-orders-of-magnitude higher than current devices, and a highly competitive limit of detection of 0.243 nM. These remarkable figures-of-merit will open new windows for applications such as electrochemical recording from a single neuron.

AlkuperäiskieliEnglanti
Artikkeli2303872
Sivumäärä12
JulkaisuAdvanced Healthcare Materials
Vuosikerta13
Numero18
Varhainen verkossa julkaisun päivämäärä5 kesäk. 2024
DOI - pysyväislinkit
TilaJulkaistu - 17 heinäk. 2024
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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