Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Tutkijat

  • Manuel Hartweg
  • Charlotte J.C. Edwards-Gayle
  • Elham Radvar
  • Dominic Collis
  • Mehedi Reza
  • Michael Kaupp
  • Jan Steinkoenig
  • Janne Ruokolainen

  • Robert Rambo
  • Christopher Barner-Kowollik
  • Ian W. Hamley
  • Helena S. Azevedo
  • C. Remzi Becer

Organisaatiot

  • Queen Mary University of London
  • University of Reading
  • Diamond Light Source Ltd
  • Karlsruhe Institute of Technology
  • Queensland University of Technology

Kuvaus

Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi multicomponent reaction has not yet been studied. Herein, we report a synthetic strategy that enables both the modification of peptides as well as the generation of sequence-defined peptide-peptoid hybrid structures. Our synthetic methodology rests on the fusion of solid phase peptide synthesis with Ugi multicomponent reactions. We evidence that a diversity of chemical functionalities can be inserted into peptides or used in the design of peptide-peptoid hybrids exploiting a wide functional array including amines, carboxylic acids, hydrocarbons, carbohydrates as well as polymers, introducing a sequence-defined synthetic platform technology for precision peptoid hybrids.

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut482-489
Sivumäärä8
JulkaisuPolymer Chemistry
Vuosikerta9
Numero4
TilaJulkaistu - 28 tammikuuta 2018
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

ID: 17485470