Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities

Manuel Hartweg, Charlotte J.C. Edwards-Gayle, Elham Radvar, Dominic Collis, Mehedi Reza, Michael Kaupp, Jan Steinkoenig, Janne Ruokolainen, Robert Rambo, Christopher Barner-Kowollik, Ian W. Hamley, Helena S. Azevedo, C. Remzi Becer*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

12 Sitaatiot (Scopus)

Abstrakti

Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi multicomponent reaction has not yet been studied. Herein, we report a synthetic strategy that enables both the modification of peptides as well as the generation of sequence-defined peptide-peptoid hybrid structures. Our synthetic methodology rests on the fusion of solid phase peptide synthesis with Ugi multicomponent reactions. We evidence that a diversity of chemical functionalities can be inserted into peptides or used in the design of peptide-peptoid hybrids exploiting a wide functional array including amines, carboxylic acids, hydrocarbons, carbohydrates as well as polymers, introducing a sequence-defined synthetic platform technology for precision peptoid hybrids.

AlkuperäiskieliEnglanti
Sivut482-489
Sivumäärä8
JulkaisuPolymer Chemistry
Vuosikerta9
Numero4
DOI - pysyväislinkit
TilaJulkaistu - 28 tammikuuta 2018
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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  • Siteeraa tätä

    Hartweg, M., Edwards-Gayle, C. J. C., Radvar, E., Collis, D., Reza, M., Kaupp, M., ... Becer, C. R. (2018). Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities. Polymer Chemistry, 9(4), 482-489. https://doi.org/10.1039/c7py01953j