Standard of hygiene and immune adaptation in newborn infants

Henna Kallionpää, Essi Laajala, Viveka Öling, Taina Härkönen, Vallo Tillmann, Natalya V. Dorshakova, Jorma Ilonen, Harri Lähdesmäki, Mikael Knip, Riitta Lahesmaa

    Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

    26 Sitaatiot (Scopus)
    175 Lataukset (Pure)

    Abstrakti

    The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical cord blood RNA samples from infants born in Finland (modern society), Estonia (rapidly developing society) and the Republic of Karelia, Russia (poor economic conditions). The whole blood transcriptome of Finnish and Estonian neonates differed from their Karelian counterparts, suggesting exposure to toll-like receptor (TLR) ligands and a more matured immune response in infants born in Karelia. These results further support the concept of a conspicuous plasticity in the developing immune system: the environmental factors that play a role in the susceptibility/protection towards immune-mediated diseases begin to shape the neonatal immunity already in utero and direct the maturation in accordance with the surrounding microbial milieu.
    AlkuperäiskieliEnglanti
    Sivut136-147
    JulkaisuCLINICAL IMMUNOLOGY
    Vuosikerta155
    Numero1
    DOI - pysyväislinkit
    TilaJulkaistu - 2014
    OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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