Solid-phase bromination and Suzuki coupling of 2-carboxyindoles

J. Tois; R. Franzén; O. Aitio; I. Laakso; J. Huuskonen; J. Taskinen

doi:10.2174/1386207013330887

Solid-phase bromination and Suzuki coupling of 2-carboxyindoles

J. Tois^*
, R. Franzén
, O. Aitio
, I. Laakso
, J. Huuskonen
, J. Taskinen

^*Tämän työn vastaava kirjoittaja

Ei julkaistu Aalto-yliopiston affiliaatiolla

University of Helsinki

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

9 Sitaatiot (Scopus)

Abstrakti

As part of an ongoing lead discovery project we have developed a convenient method for the modification and substitution of indole moieties at the 3-position. Selective bromination of three different 2-carboxyindoles was followed by Suzuki cross-coupling with aryl and heteroaryl boronic acids on a Merrifield resin solid-phase. After column chromatography, yields of the 3- substituted indoles ranged from 42-98%.

Alkuperäiskieli	Englanti
Sivut	521-524
Sivumäärä	4
Julkaisu	Combinatorial Chemistry and High Throughput Screening
Vuosikerta	4
Numero	6
DOI - pysyväislinkit	https://doi.org/10.2174/1386207013330887
Tila	Julkaistu - 2001
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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10.2174/1386207013330887

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title = "Solid-phase bromination and Suzuki coupling of 2-carboxyindoles",

abstract = "As part of an ongoing lead discovery project we have developed a convenient method for the modification and substitution of indole moieties at the 3-position. Selective bromination of three different 2-carboxyindoles was followed by Suzuki cross-coupling with aryl and heteroaryl boronic acids on a Merrifield resin solid-phase. After column chromatography, yields of the 3- substituted indoles ranged from 42-98\%.",

author = "J. Tois and R. Franz{\'e}n and O. Aitio and I. Laakso and J. Huuskonen and J. Taskinen",

year = "2001",

doi = "10.2174/1386207013330887",

language = "English",

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pages = "521--524",

journal = "Combinatorial Chemistry and High Throughput Screening",

issn = "1386-2073",

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TY - JOUR

T1 - Solid-phase bromination and Suzuki coupling of 2-carboxyindoles

AU - Tois, J.

AU - Franzén, R.

AU - Aitio, O.

AU - Laakso, I.

AU - Huuskonen, J.

AU - Taskinen, J.

PY - 2001

Y1 - 2001

N2 - As part of an ongoing lead discovery project we have developed a convenient method for the modification and substitution of indole moieties at the 3-position. Selective bromination of three different 2-carboxyindoles was followed by Suzuki cross-coupling with aryl and heteroaryl boronic acids on a Merrifield resin solid-phase. After column chromatography, yields of the 3- substituted indoles ranged from 42-98%.

AB - As part of an ongoing lead discovery project we have developed a convenient method for the modification and substitution of indole moieties at the 3-position. Selective bromination of three different 2-carboxyindoles was followed by Suzuki cross-coupling with aryl and heteroaryl boronic acids on a Merrifield resin solid-phase. After column chromatography, yields of the 3- substituted indoles ranged from 42-98%.

UR - https://www.scopus.com/pages/publications/0034861953

U2 - 10.2174/1386207013330887

DO - 10.2174/1386207013330887

M3 - Article

C2 - 11562256

AN - SCOPUS:0034861953

SN - 1386-2073

VL - 4

SP - 521

EP - 524

JO - Combinatorial Chemistry and High Throughput Screening

JF - Combinatorial Chemistry and High Throughput Screening

IS - 6

ER -

Solid-phase bromination and Suzuki coupling of 2-carboxyindoles

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