Social touch modulates endogenous μ-opioid system activity in humans

Tutkimustuotos: Lehtiartikkeli

Tutkijat

Organisaatiot

  • Turku PET Centre
  • University of Oxford

Kuvaus

In non-human primates, opioid-receptor blockade increases social grooming, and the endogenous opioid system has therefore been hypothesized to support maintenance of long-term relationships in humans as well. Here we tested whether social touch modulates opioidergic activation in humans using in vivo positron emission tomography (PET). Eighteen male participants underwent two PET scans with [11C]carfentanil, a ligand specific to μ-opioid receptors (MOR). During the social touch scan, the participants lay in the scanner while their partners caressed their bodies in a non-sexual fashion. In the baseline scan, participants lay alone in the scanner. Social touch triggered pleasurable sensations and increased MOR availability in the thalamus, striatum, and frontal, cingulate, and insular cortices. Modulation of activity of the opioid system by social touching might provide a neurochemical mechanism reinforcing social bonds between humans.

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut242-247
Sivumäärä6
JulkaisuNeuroImage
Vuosikerta138
TilaJulkaistu - 1 syyskuuta 2016
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

ID: 6487951