Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

Steven Kirkham; Valeria Castelletto; Ian William Hamley; Katsuaki Inoue; Robert Rambo; Mehedi Reza; Janne Ruokolainen

doi:10.1002/cphc.201600308

Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

Steven Kirkham
, Valeria Castelletto
, Ian William Hamley^*
, Katsuaki Inoue
, Robert Rambo
, Mehedi Reza
, Janne Ruokolainen

^*Tämän työn vastaava kirjoittaja

University of Reading
Harwell Science and Innovation Campus

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

40 Sitaatiot (Scopus)

Abstrakti

The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl₂, in contrast to claims in the literature that CaCl₂ is required for micellization.

Alkuperäiskieli	Englanti
Sivut	2118 – 2122
Julkaisu	ChemPhysChem
Vuosikerta	17
Numero	14
DOI - pysyväislinkit	https://doi.org/10.1002/cphc.201600308
Tila	Julkaistu - 18 heinäk. 2016
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Pääsy asiakirjaan

10.1002/cphc.201600308

http://centaur.reading.ac.uk/66618/

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title = "Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride",

abstract = "The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2, in contrast to claims in the literature that CaCl2 is required for micellization.",

keywords = "Antimicrobial peptides, Lipopeptide, Micelles, Secondary structure, Self-assembly",

author = "Steven Kirkham and Valeria Castelletto and Hamley, \{Ian William\} and Katsuaki Inoue and Robert Rambo and Mehedi Reza and Janne Ruokolainen",

year = "2016",

month = jul,

day = "18",

doi = "10.1002/cphc.201600308",

language = "English",

volume = "17",

pages = "2118 – 2122",

journal = "ChemPhysChem",

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publisher = "Wiley",

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TY - JOUR

T1 - Self-Assembly of the Cyclic Lipopeptide Daptomycin

T2 - Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

AU - Kirkham, Steven

AU - Castelletto, Valeria

AU - Hamley, Ian William

AU - Inoue, Katsuaki

AU - Rambo, Robert

AU - Reza, Mehedi

AU - Ruokolainen, Janne

PY - 2016/7/18

Y1 - 2016/7/18

N2 - The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2, in contrast to claims in the literature that CaCl2 is required for micellization.

AB - The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2, in contrast to claims in the literature that CaCl2 is required for micellization.

KW - Antimicrobial peptides

KW - Lipopeptide

KW - Micelles

KW - Secondary structure

KW - Self-assembly

UR - https://www.scopus.com/pages/publications/84979243775

U2 - 10.1002/cphc.201600308

DO - 10.1002/cphc.201600308

M3 - Article

SN - 1439-4235

VL - 17

SP - 2118

EP - 2122

JO - ChemPhysChem

JF - ChemPhysChem

IS - 14

ER -

Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

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