Self-Assembly of Minimal Peptoid Sequences

Valeria Castelletto*, Jani Seitsonen, Kunal M. Tewari, Abshar Hasan, Robert M. Edkins, Janne Ruokolainen, Lalit M. Pandey, Ian W. Hamley, King Hang Aaron Lau

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

1 Sitaatiot (Scopus)
7 Lataukset (Pure)

Abstrakti

Peptoids are biofunctional N-substituted glycine peptidomimics. Their self-assembly is of fundamental interest because they demonstrate alternatives to conventional peptide structures based on backbone chirality and beta-sheet hydrogen bonding. The search for self-assembling, water-soluble "minimal" sequences, be they peptide or peptidomimic, is a further challenge. Such sequences are highly desired for their compatibility with biomacromolecules and convenient synthesis for broader application. We report the self-assembly of a set of trimeric, water-soluble α-peptoids that exhibit a relatively low critical aggregation concentration (CAC ∼0.3 wt %). Cryo-EM and angle-resolved DLS show different sequence-dependent morphologies, namely uniform ca. 6 nm wide nanofibers, sheets, and clusters of globular assemblies. Absorbance and fluorescence spectroscopies indicate unique phenyl environments for ?-interactions in the highly ordered nanofibers. Assembly of our peptoids takes place when the sequences are fully ionized, representing a departure from superficially similar amyloid-type hydrogen-bonded peptide nanostructures and expanding the horizons of assembly for sequence-specific bio- and biomimetic macromolecules.

AlkuperäiskieliEnglanti
Sivut494-499
Sivumäärä6
JulkaisuACS Macro Letters
Vuosikerta2020
Numero9
DOI - pysyväislinkit
TilaJulkaistu - 19 maaliskuuta 2020
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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  • Siteeraa tätä

    Castelletto, V., Seitsonen, J., Tewari, K. M., Hasan, A., Edkins, R. M., Ruokolainen, J., ... Lau, K. H. A. (2020). Self-Assembly of Minimal Peptoid Sequences. ACS Macro Letters, 2020(9), 494-499. https://doi.org/10.1021/acsmacrolett.9b01010