Search for antibody catalysts for the ene reaction

T Hase; G Brunow; A Hase; M Kodaka; C Neagu; Tarja Nevanen; T Teeri; Olle Teleman; E Tiainen; Jari YliKauhaluoma; Ari Yliniemelä

Search for antibody catalysts for the ene reaction

T Hase^*, G Brunow, A Hase, M Kodaka, C Neagu, Tarja Nevanen, T Teeri, Olle Teleman, E Tiainen, Jari YliKauhaluoma, Ari Yliniemelä

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VTT Technical Research Centre of Finland Ltd.

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

Abstrakti

The design, computational studies and synthesis of transition state analogs for an ene reaction are described. The most promising analogs were used to elicit antibodies that should catalyze an ene reaction between maleimide and 1-decene. Preliminary results indicate that successful catalytic antibodies for the ene reaction can be produced in this manner. In parallel, an antibody library is being developed for the same purpose.

Alkuperäiskieli	Englanti
Sivut	605-608
Sivumäärä	4
Julkaisu	Pure and Applied Chemistry
Vuosikerta	68
Numero	3
Tila	Julkaistu - maalisk. 1996
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu
Tapahtuma	International Conference on Organic Synthesis - Bangalore, Intia Kesto: 11 jouluk. 1994 → 16 jouluk. 1994 Konferenssinumero: 10

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@article{4606369e276844c3b7e51521f016a700,

title = "Search for antibody catalysts for the ene reaction",

abstract = "The design, computational studies and synthesis of transition state analogs for an ene reaction are described. The most promising analogs were used to elicit antibodies that should catalyze an ene reaction between maleimide and 1-decene. Preliminary results indicate that successful catalytic antibodies for the ene reaction can be produced in this manner. In parallel, an antibody library is being developed for the same purpose.",

author = "T Hase and G Brunow and A Hase and M Kodaka and C Neagu and Tarja Nevanen and T Teeri and Olle Teleman and E Tiainen and Jari YliKauhaluoma and Ari Yliniemel{\"a}",

year = "1996",

month = mar,

language = "English",

volume = "68",

pages = "605--608",

journal = "Pure and Applied Chemistry",

issn = "0033-4545",

publisher = "Blackwell Science",

number = "3",

note = "International Conference on Organic Synthesis ; Conference date: 11-12-1994 Through 16-12-1994",

}

TY - JOUR

T1 - Search for antibody catalysts for the ene reaction

AU - Hase, T

AU - Brunow, G

AU - Hase, A

AU - Kodaka, M

AU - Neagu, C

AU - Nevanen, Tarja

AU - Teeri, T

AU - Teleman, Olle

AU - Tiainen, E

AU - YliKauhaluoma, Jari

AU - Yliniemelä, Ari

N1 - Conference code: 10

PY - 1996/3

Y1 - 1996/3

N2 - The design, computational studies and synthesis of transition state analogs for an ene reaction are described. The most promising analogs were used to elicit antibodies that should catalyze an ene reaction between maleimide and 1-decene. Preliminary results indicate that successful catalytic antibodies for the ene reaction can be produced in this manner. In parallel, an antibody library is being developed for the same purpose.

AB - The design, computational studies and synthesis of transition state analogs for an ene reaction are described. The most promising analogs were used to elicit antibodies that should catalyze an ene reaction between maleimide and 1-decene. Preliminary results indicate that successful catalytic antibodies for the ene reaction can be produced in this manner. In parallel, an antibody library is being developed for the same purpose.

M3 - Article

SN - 0033-4545

VL - 68

SP - 605

EP - 608

JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

IS - 3

T2 - International Conference on Organic Synthesis

Y2 - 11 December 1994 through 16 December 1994

ER -

Search for antibody catalysts for the ene reaction

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