Reorganization of functionally connected brain subnetworks in high-functioning autism

Tutkimustuotos: Lehtiartikkeli

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Reorganization of functionally connected brain subnetworks in high-functioning autism. / Glerean, Enrico; Pan, Raj K.; Salmi, Juha; Kujala, Rainer; Lahnakoski, Juha M.; Roine, Ulrika; Nummenmaa, Lauri; Leppämäki, Sami; Nieminen-von Wendt, Taina; Tani, Pekka; Saramäki, Jari; Sams, Mikko; Jääskeläinen, Iiro P.

julkaisussa: Human Brain Mapping, Vuosikerta 37, Nro 3, 01.03.2016, s. 1066-1079.

Tutkimustuotos: Lehtiartikkeli

Harvard

Glerean, E, Pan, RK, Salmi, J, Kujala, R, Lahnakoski, JM, Roine, U, Nummenmaa, L, Leppämäki, S, Nieminen-von Wendt, T, Tani, P, Saramäki, J, Sams, M & Jääskeläinen, IP 2016, 'Reorganization of functionally connected brain subnetworks in high-functioning autism', Human Brain Mapping, Vuosikerta. 37, Nro 3, Sivut 1066-1079. https://doi.org/10.1002/hbm.23084

APA

Vancouver

Author

Glerean, Enrico ; Pan, Raj K. ; Salmi, Juha ; Kujala, Rainer ; Lahnakoski, Juha M. ; Roine, Ulrika ; Nummenmaa, Lauri ; Leppämäki, Sami ; Nieminen-von Wendt, Taina ; Tani, Pekka ; Saramäki, Jari ; Sams, Mikko ; Jääskeläinen, Iiro P. / Reorganization of functionally connected brain subnetworks in high-functioning autism. Julkaisussa: Human Brain Mapping. 2016 ; Vuosikerta 37, Nro 3. Sivut 1066-1079.

Bibtex - Lataa

@article{b4e79a256dc040a6926f0b00e925f536,
title = "Reorganization of functionally connected brain subnetworks in high-functioning autism",
abstract = "Previous functional connectivity studies have found both hypo- and hyper-connectivity in brains of individuals having autism spectrum disorder (ASD). Here we studied abnormalities in functional brain subnetworks in high-functioning individuals with ASD during free viewing of a movie containing social cues and interactions. Twenty-six subjects (13 with ASD) watched a 68-min movie during functional magnetic resonance imaging. For each subject, we computed Pearson's correlation between haemodynamic time-courses of each pair of 6-mm isotropic voxels. From the whole-brain functional networks, we derived individual and group-level subnetworks using graph theory. Scaled inclusivity was then calculated between all subject pairs to estimate intersubject similarity of connectivity structure of each subnetwork. Additional 54 individuals (27 with ASD) from the ABIDE resting-state database were included to test the reproducibility of the results. Between-group differences were observed in the composition of default-mode and ventro-temporal-limbic (VTL) subnetworks. The VTL subnetwork included amygdala, striatum, thalamus, parahippocampal, fusiform, and inferior temporal gyri. Further, VTL subnetwork similarity between subject pairs correlated significantly with similarity of symptom gravity measured with autism quotient. This correlation was observed also within the controls, and in the reproducibility dataset with ADI-R and ADOS scores. Our results highlight how the reorganization of functional subnetworks in individuals with ASD clarifies the mixture of hypo- and hyper-connectivity findings. Importantly, only the functional organization of the VTL subnetwork emerges as a marker of inter-individual similarities that co-vary with behavioral measures across all participants. These findings suggest a pivotal role of ventro-temporal and limbic systems in autism. Hum Brain Mapp 37:1066-1079, 2016.",
keywords = "Autism spectrum disorder, FMRI, Functional connectivity, Graph theory, Intersubject similarity, Network modularity",
author = "Enrico Glerean and Pan, {Raj K.} and Juha Salmi and Rainer Kujala and Lahnakoski, {Juha M.} and Ulrika Roine and Lauri Nummenmaa and Sami Lepp{\"a}m{\"a}ki and {Nieminen-von Wendt}, Taina and Pekka Tani and Jari Saram{\"a}ki and Mikko Sams and J{\"a}{\"a}skel{\"a}inen, {Iiro P.}",
note = "VK: Saram{\"a}ki, J.",
year = "2016",
month = "3",
day = "1",
doi = "10.1002/hbm.23084",
language = "English",
volume = "37",
pages = "1066--1079",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley",
number = "3",

}

RIS - Lataa

TY - JOUR

T1 - Reorganization of functionally connected brain subnetworks in high-functioning autism

AU - Glerean, Enrico

AU - Pan, Raj K.

AU - Salmi, Juha

AU - Kujala, Rainer

AU - Lahnakoski, Juha M.

AU - Roine, Ulrika

AU - Nummenmaa, Lauri

AU - Leppämäki, Sami

AU - Nieminen-von Wendt, Taina

AU - Tani, Pekka

AU - Saramäki, Jari

AU - Sams, Mikko

AU - Jääskeläinen, Iiro P.

N1 - VK: Saramäki, J.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Previous functional connectivity studies have found both hypo- and hyper-connectivity in brains of individuals having autism spectrum disorder (ASD). Here we studied abnormalities in functional brain subnetworks in high-functioning individuals with ASD during free viewing of a movie containing social cues and interactions. Twenty-six subjects (13 with ASD) watched a 68-min movie during functional magnetic resonance imaging. For each subject, we computed Pearson's correlation between haemodynamic time-courses of each pair of 6-mm isotropic voxels. From the whole-brain functional networks, we derived individual and group-level subnetworks using graph theory. Scaled inclusivity was then calculated between all subject pairs to estimate intersubject similarity of connectivity structure of each subnetwork. Additional 54 individuals (27 with ASD) from the ABIDE resting-state database were included to test the reproducibility of the results. Between-group differences were observed in the composition of default-mode and ventro-temporal-limbic (VTL) subnetworks. The VTL subnetwork included amygdala, striatum, thalamus, parahippocampal, fusiform, and inferior temporal gyri. Further, VTL subnetwork similarity between subject pairs correlated significantly with similarity of symptom gravity measured with autism quotient. This correlation was observed also within the controls, and in the reproducibility dataset with ADI-R and ADOS scores. Our results highlight how the reorganization of functional subnetworks in individuals with ASD clarifies the mixture of hypo- and hyper-connectivity findings. Importantly, only the functional organization of the VTL subnetwork emerges as a marker of inter-individual similarities that co-vary with behavioral measures across all participants. These findings suggest a pivotal role of ventro-temporal and limbic systems in autism. Hum Brain Mapp 37:1066-1079, 2016.

AB - Previous functional connectivity studies have found both hypo- and hyper-connectivity in brains of individuals having autism spectrum disorder (ASD). Here we studied abnormalities in functional brain subnetworks in high-functioning individuals with ASD during free viewing of a movie containing social cues and interactions. Twenty-six subjects (13 with ASD) watched a 68-min movie during functional magnetic resonance imaging. For each subject, we computed Pearson's correlation between haemodynamic time-courses of each pair of 6-mm isotropic voxels. From the whole-brain functional networks, we derived individual and group-level subnetworks using graph theory. Scaled inclusivity was then calculated between all subject pairs to estimate intersubject similarity of connectivity structure of each subnetwork. Additional 54 individuals (27 with ASD) from the ABIDE resting-state database were included to test the reproducibility of the results. Between-group differences were observed in the composition of default-mode and ventro-temporal-limbic (VTL) subnetworks. The VTL subnetwork included amygdala, striatum, thalamus, parahippocampal, fusiform, and inferior temporal gyri. Further, VTL subnetwork similarity between subject pairs correlated significantly with similarity of symptom gravity measured with autism quotient. This correlation was observed also within the controls, and in the reproducibility dataset with ADI-R and ADOS scores. Our results highlight how the reorganization of functional subnetworks in individuals with ASD clarifies the mixture of hypo- and hyper-connectivity findings. Importantly, only the functional organization of the VTL subnetwork emerges as a marker of inter-individual similarities that co-vary with behavioral measures across all participants. These findings suggest a pivotal role of ventro-temporal and limbic systems in autism. Hum Brain Mapp 37:1066-1079, 2016.

KW - Autism spectrum disorder

KW - FMRI

KW - Functional connectivity

KW - Graph theory

KW - Intersubject similarity

KW - Network modularity

UR - http://www.scopus.com/inward/record.url?scp=84958292303&partnerID=8YFLogxK

U2 - 10.1002/hbm.23084

DO - 10.1002/hbm.23084

M3 - Article

VL - 37

SP - 1066

EP - 1079

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 3

ER -

ID: 1591229