Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration

Haniyeh Najafi, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali*, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliReview ArticleScientificvertaisarvioitu

2 Sitaatiot (Scopus)

Abstrakti

The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance, especially in societies with a large elderly population. Self-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility, tunable mechanical stability, injectability, trigger capability, lack of immunogenic reactions, and the ability to load cells and active pharmaceutical agents for tissue regeneration. Peptide-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals, which can mimic the extracellular matrix. Thus, peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional methods. This review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration, including ionic self-complementary peptides, amphiphilic (surfactant-like) peptides, and triple-helix (collagen-like) peptides. Special attention is given to the main bioactive peptides, the role and importance of self-assembled peptide hydrogels, and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.

AlkuperäiskieliEnglanti
Sivut735-756
Sivumäärä22
JulkaisuBio-Design and Manufacturing
Vuosikerta4
Numero4
Varhainen verkossa julkaisun päivämäärä20 heinäk. 2021
DOI - pysyväislinkit
TilaJulkaistu - jouluk. 2021
OKM-julkaisutyyppiA2 Arvio tiedejulkaisuussa (artikkeli)

Sormenjälki

Sukella tutkimusaiheisiin 'Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.

Siteeraa tätä