PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

MERJA PENTTILÄ,; MARKKU SALOHEIMO,; ANNE KANERVA,; JARI NATUNEN,; ANNE HUUSKONEN,; CHRISTOPHER LANDOWSKI,; JUHANI SAARINEN,; ANN WESTERHOLM-PARVINEN,; ANNA-LIISA HÄNNINEN,; NOORA SALOVUORI,

PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

MERJA PENTTILÄ, (Keksijä)
, MARKKU SALOHEIMO, (Keksijä)
, ANNE KANERVA, (Keksijä)
, JARI NATUNEN, (Keksijä)
, ANNE HUUSKONEN, (Keksijä)
, CHRISTOPHER LANDOWSKI, (Keksijä)
, JUHANI SAARINEN, (Keksijä)
, ANN WESTERHOLM-PARVINEN, (Keksijä)
, ANNA-LIISA HÄNNINEN, (Keksijä)
, NOORA SALOVUORI, (Keksijä)

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Tutkimustuotos: Patentti › Patent

Abstrakti

The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.

Alkuperäiskieli	Englanti
Patenttinumero	MX2014008272
IPC	C12P 21/ 02 A I
Prioriteetti päiväys	04/01/2013
Tila	Julkaistu - 24 helmik. 2015
OKM-julkaisutyyppi	H1 Myönnetty patentti

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title = "PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.",

abstract = "The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.",

author = "MERJA PENTTIL{\"A}, and MARKKU SALOHEIMO, and ANNE KANERVA, and JARI NATUNEN, and ANNE HUUSKONEN, and CHRISTOPHER LANDOWSKI, and JUHANI SAARINEN, and ANN WESTERHOLM-PARVINEN, and ANNA-LIISA H{\"A}NNINEN, and NOORA SALOVUORI,",

year = "2015",

month = feb,

day = "24",

language = "English",

type = "Patent",

note = "MX2014008272; C12P 21/ 02 A I",

}

TY - PAT

T1 - PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

AU - PENTTILÄ,, MERJA

AU - SALOHEIMO,, MARKKU

AU - KANERVA,, ANNE

AU - NATUNEN,, JARI

AU - HUUSKONEN,, ANNE

AU - LANDOWSKI,, CHRISTOPHER

AU - SAARINEN,, JUHANI

AU - WESTERHOLM-PARVINEN,, ANN

AU - HÄNNINEN,, ANNA-LIISA

AU - SALOVUORI,, NOORA

PY - 2015/2/24

Y1 - 2015/2/24

N2 - The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.

AB - The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.

M3 - Patent

M1 - MX2014008272

ER -

PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

Abstrakti

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