Process control and monitoring of reactive crystallization of L-glutamic acid

Hannu Alatalo*, Henry Hatakka, Jarno Kohonen, Satu Pia Reinikainen, Marjatta Louhi-Kultanen

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

26 Sitaatiot (Scopus)

Abstrakti

The aim of the present study was to investigate feedback control of a reactive crystallization process. The present study built up a control structure needed to control the driving force of reactive crystallization using the feed rate of added acid. The concentration of the crystallizing compound and pH was used to compute feedback in the closed-loop control of semi-batch precipitation. The concentration of L-glutamic acid was determined from measured MID-IR ATR-FTIR spectra based on a multivariate model. Dynamic change of set value was based on the mass of added sulfuric acid and pH. The studied properties of the product crystals were polymorphism and crystal size. The polymorphic composition was analyzed with a Raman spectrometer and was expressed by mass fraction of the a-polymorph. The obtained results showed that the developed feedback process control system allows effective control of forming of polymorphs.

AlkuperäiskieliEnglanti
Sivut2063-2076
Sivumäärä14
JulkaisuAIChE Journal
Vuosikerta56
Numero8
DOI - pysyväislinkit
TilaJulkaistu - elokuuta 2010
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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