Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release

Tutkimustuotos: Lehtiartikkeli

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Physically and chemically cross-linked cellulose cryogels : Structure, properties and application for controlled release. / Ciolacu, Diana; Rudaz, Cyrielle; Vasilescu, Mihai; Budtova, Tatiana.

julkaisussa: Carbohydrate Polymers, Vuosikerta 151, 20.10.2016, s. 392-400.

Tutkimustuotos: Lehtiartikkeli

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Ciolacu, Diana ; Rudaz, Cyrielle ; Vasilescu, Mihai ; Budtova, Tatiana. / Physically and chemically cross-linked cellulose cryogels : Structure, properties and application for controlled release. Julkaisussa: Carbohydrate Polymers. 2016 ; Vuosikerta 151. Sivut 392-400.

Bibtex - Lataa

@article{e8e2fb8bbee945699fd26e25371f8584,
title = "Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release",
abstract = "Porous cellulose matrices were prepared via cellulose dissolution in 8 wt{\%} NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.",
keywords = "Cellulose, Controlled release, Cross-linking, Cryogel, Hydrogel, Swelling",
author = "Diana Ciolacu and Cyrielle Rudaz and Mihai Vasilescu and Tatiana Budtova",
year = "2016",
month = "10",
day = "20",
doi = "10.1016/j.carbpol.2016.05.084",
language = "English",
volume = "151",
pages = "392--400",
journal = "Carbohydrate Polymers",
issn = "0144-8617",

}

RIS - Lataa

TY - JOUR

T1 - Physically and chemically cross-linked cellulose cryogels

T2 - Structure, properties and application for controlled release

AU - Ciolacu, Diana

AU - Rudaz, Cyrielle

AU - Vasilescu, Mihai

AU - Budtova, Tatiana

PY - 2016/10/20

Y1 - 2016/10/20

N2 - Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.

AB - Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.

KW - Cellulose

KW - Controlled release

KW - Cross-linking

KW - Cryogel

KW - Hydrogel

KW - Swelling

UR - http://www.scopus.com/inward/record.url?scp=84975496318&partnerID=8YFLogxK

U2 - 10.1016/j.carbpol.2016.05.084

DO - 10.1016/j.carbpol.2016.05.084

M3 - Article

VL - 151

SP - 392

EP - 400

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

ER -

ID: 9012483