Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Tutkijat

Organisaatiot

  • Petru Poni Institute of Macromolecular Chemistry
  • CNRS UMR 7635
  • Babes-Bolyai University

Kuvaus

Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut392-400
Sivumäärä9
JulkaisuCarbohydrate Polymers
Vuosikerta151
TilaJulkaistu - 20 lokakuuta 2016
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

ID: 9012483