Phthalocyanine–DNA origami complexes with enhanced stability and optical properties

Ahmed Shaukat; Eduardo Anaya-Plaza; Sofia Julin; Veikko Linko; Tomas Torres; Andrés de la Escosura; Mauri A. Kostiainen

doi:10.1039/D0CC01916J

Phthalocyanine–DNA origami complexes with enhanced stability and optical properties

Ahmed Shaukat, Eduardo Anaya-Plaza, Sofia Julin, Veikko Linko, Tomas Torres, Andrés de la Escosura, Mauri A. Kostiainen

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

16 Sitaatiot (Scopus)

43 Lataukset (Pure)

Abstrakti

In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy.

Alkuperäiskieli	Englanti
Sivut	7341-7344
Sivumäärä	4
Julkaisu	Chemical Communications
Vuosikerta	56
Numero	53
Varhainen verkossa julkaisun päivämäärä	27 toukok. 2020
DOI - pysyväislinkit	https://doi.org/10.1039/D0CC01916J
Tila	Julkaistu - 7 heinäk. 2020
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Pääsy asiakirjaan

10.1039/D0CC01916JLisenssi: CC BY-NC

Phthalocyanine-DNA origami complexesFinal published version, 2,86 MBLisenssi: CC BY-NC

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Linkki julkaisuun Scopuksessa

BiHyOMat: BioHybrid Optoelectronic Materials
Kostiainen, M. & Anaya Plaza, E.
01/06/2018 → 20/06/2020
Projekti: EU: Other research funding
SYNVIRO: Polyelektrolyyttien Enkapsulointi Synteettisen Virologian Keinoin (SYNVIRO)
Kostiainen, M., Ahmed, A., Anaya Plaza, E., Liu, Q., Julin, S., Välimäki, S. & Korpi, A.
01/09/2017 → 31/08/2021
Projekti: Academy of Finland: Other research funding
Räätälöityjä molekyylikoneita nukleiinihappoihin perustuvalla nanoteknologialla
Linko, V.
01/09/2015 → 31/08/2018
Projekti: Academy of Finland: Other research funding

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title = "Phthalocyanine–DNA origami complexes with enhanced stability and optical properties",

abstract = "In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy.",

author = "Ahmed Shaukat and Eduardo Anaya-Plaza and Sofia Julin and Veikko Linko and Tomas Torres and Escosura, {Andr{\'e}s de la} and Kostiainen, {Mauri A.}",

note = "| openaire: EC/H2020/794536/EU//BiHyOMat",

year = "2020",

month = jul,

day = "7",

doi = "10.1039/D0CC01916J",

language = "English",

volume = "56",

pages = "7341--7344",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "53",

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TY - JOUR

T1 - Phthalocyanine–DNA origami complexes with enhanced stability and optical properties

AU - Shaukat, Ahmed

AU - Anaya-Plaza, Eduardo

AU - Julin, Sofia

AU - Linko, Veikko

AU - Torres, Tomas

AU - Escosura, Andrés de la

AU - Kostiainen, Mauri A.

N1 - | openaire: EC/H2020/794536/EU//BiHyOMat

PY - 2020/7/7

Y1 - 2020/7/7

N2 - In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy.

AB - In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy.

UR - http://www.scopus.com/inward/record.url?scp=85087528777&partnerID=8YFLogxK

U2 - 10.1039/D0CC01916J

DO - 10.1039/D0CC01916J

M3 - Article

C2 - 32483566

SN - 1359-7345

VL - 56

SP - 7341

EP - 7344

JO - Chemical Communications

JF - Chemical Communications

IS - 53

ER -

Phthalocyanine–DNA origami complexes with enhanced stability and optical properties

Abstrakti

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Muut tiedostot ja linkit

Sormenjälki

Projektit

BiHyOMat: BioHybrid Optoelectronic Materials

SYNVIRO: Polyelektrolyyttien Enkapsulointi Synteettisen Virologian Keinoin (SYNVIRO)

Räätälöityjä molekyylikoneita nukleiinihappoihin perustuvalla nanoteknologialla

Laitteet

Biotalousinfrastruktuuri

OtaNano Nanomikroskopiakeskus

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