Photoluminescent Hybrids of Cellulose Nanocrystals and Carbon Quantum Dots as Cytocompatible Probes for in Vitro Bioimaging

Jiaqi Guo, Dongfei Liu, Ilari Filpponen*, Leena Sisko Johansson, Jani Markus Malho, Sakeena Quraishi, Falk Liebner, Hélder A. Santos, Orlando J. Rojas

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

43 Sitaatiot (Scopus)

Abstrakti

We present an approach to construct biocompatible and photoluminescent hybrid materials comprised of carbon quantum dots (CQDs) and TEMPO-oxidized cellulose nanocrystals (TO-CNCs). First, the amino-functionalized carbon quantum dots (NH2-CQDs) were synthesized using a simple microwave method, and the TO-CNCs were prepared by hydrochloric acid (HCl) hydrolysis followed by TEMPO-mediated oxidation. The conjugation of NH2-CQDs and TO-CNCs was conducted via carbodiimide-assisted coupling chemistry. The synthesized TO-CNC@CQD hybrid nanomaterials were characterized using X-ray photoelectron spectroscopy, cryo-transmittance electron microscopy, confocal microscopy, and fluorescence spectroscopy. Finally, the interactions of TO-CNC@CQD hybrids with HeLa and RAW 264.7 macrophage cells were investigated in vitro. Cell viability tests suggest the surface conjugation with NH2-CQDs not only improved the cytocompatibility of TO-CNCs, but also enhanced their cellular association and internalization on both HeLa and RAW 264.7 cells after 4 and 24 h incubation.

AlkuperäiskieliEnglanti
Sivut2045-2055
Sivumäärä11
JulkaisuBiomacromolecules
Vuosikerta18
Numero7
DOI - pysyväislinkit
TilaJulkaistu - 10 heinäkuuta 2017
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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