PH-mediated regulation of polymer transport through SiN pores

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PH-mediated regulation of polymer transport through SiN pores. / Buyukdagli, Sahin; Ala-Nissila, T.

julkaisussa: EPL, Vuosikerta 123, Nro 3, 38003, 01.08.2018, s. 1-7.

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Buyukdagli, Sahin ; Ala-Nissila, T. / PH-mediated regulation of polymer transport through SiN pores. Julkaisussa: EPL. 2018 ; Vuosikerta 123, Nro 3. Sivut 1-7.

Bibtex - Lataa

@article{0da05c511f8c4befa290c5aff7efd5f7,
title = "PH-mediated regulation of polymer transport through SiN pores",
abstract = "We characterize the pH-controlled polymer capture and transport through silicon nitride (SiN) pores subject to protonation. A charge regulation model able to reproduce the experimental zeta potential of SiN pores is coupled with electrohydrodynamic polymer transport equations. The formalism can quantitatively explain the experimentally observed non-monotonic pH dependence of avidin conductivity in terms of the interplay between the electroosmotic and electrophoretic drag forces on the protein. We also scrutinize the DNA conductivity of SiN pores. We show that in the low-pH regime where the amphoteric pore is cationic, DNA-pore attraction acts as an electrostatic trap. This provides a favorable condition for fast polymer capture and extended translocation required for accurate polymer sequencing.",
author = "Sahin Buyukdagli and T. Ala-Nissila",
year = "2018",
month = "8",
day = "1",
doi = "10.1209/0295-5075/123/38003",
language = "English",
volume = "123",
pages = "1--7",
journal = "EPL",
issn = "0295-5075",
number = "3",

}

RIS - Lataa

TY - JOUR

T1 - PH-mediated regulation of polymer transport through SiN pores

AU - Buyukdagli, Sahin

AU - Ala-Nissila, T.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - We characterize the pH-controlled polymer capture and transport through silicon nitride (SiN) pores subject to protonation. A charge regulation model able to reproduce the experimental zeta potential of SiN pores is coupled with electrohydrodynamic polymer transport equations. The formalism can quantitatively explain the experimentally observed non-monotonic pH dependence of avidin conductivity in terms of the interplay between the electroosmotic and electrophoretic drag forces on the protein. We also scrutinize the DNA conductivity of SiN pores. We show that in the low-pH regime where the amphoteric pore is cationic, DNA-pore attraction acts as an electrostatic trap. This provides a favorable condition for fast polymer capture and extended translocation required for accurate polymer sequencing.

AB - We characterize the pH-controlled polymer capture and transport through silicon nitride (SiN) pores subject to protonation. A charge regulation model able to reproduce the experimental zeta potential of SiN pores is coupled with electrohydrodynamic polymer transport equations. The formalism can quantitatively explain the experimentally observed non-monotonic pH dependence of avidin conductivity in terms of the interplay between the electroosmotic and electrophoretic drag forces on the protein. We also scrutinize the DNA conductivity of SiN pores. We show that in the low-pH regime where the amphoteric pore is cationic, DNA-pore attraction acts as an electrostatic trap. This provides a favorable condition for fast polymer capture and extended translocation required for accurate polymer sequencing.

UR - http://www.scopus.com/inward/record.url?scp=85054009598&partnerID=8YFLogxK

U2 - 10.1209/0295-5075/123/38003

DO - 10.1209/0295-5075/123/38003

M3 - Article

VL - 123

SP - 1

EP - 7

JO - EPL

JF - EPL

SN - 0295-5075

IS - 3

M1 - 38003

ER -

ID: 28605546