Pharmacological Importance of Optically Active Tetrahydro-beta-carbolines and Synthetic Approaches to Create the C1 Stereocenter

Aino E. Laine, Christopher Lood, Ari M.P. Koskinen

    Tutkimustuotos: LehtiartikkeliReview ArticleScientificvertaisarvioitu

    62 Sitaatiot (Scopus)
    107 Lataukset (Pure)

    Abstrakti

    1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a pharmacologically important
    group of compounds belonging to the indole alkaloids. C1-Substituted optically active THβCs have been the target of extensive synthetic efforts due to the presence of the scaffold in numerous natural products and synthetic targets. This review briefly summarizes the methods to obtain the C1 stereocenter and concentrates on evaluating the pharmacological importance of optically active C1-substituted THβCs, including their PDE5-inhibitory, antimalarial, antiviral and antitumor activities.
    AlkuperäiskieliEnglanti
    Sivut1544-1567
    JulkaisuMOLECULES
    Vuosikerta19
    Numero2
    DOI - pysyväislinkit
    TilaJulkaistu - 2014
    OKM-julkaisutyyppiA2 Arvio tiedejulkaisuussa (artikkeli)

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