Peripheral differentiation patterns of human T cells

Nelli Heikkilä*, Iivo Hetemäki, Silja Sormunen, Helena Isoniemi, Eliisa Kekäläinen, Jari Saramäki, T. Petteri Arstila

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

1 Lataukset (Pure)

Abstrakti

Long-term T-cell memory is dependent on the maintenance of memory T cells in the lymphoid tissues, and at the surface interfaces that provide entry routes for pathogens. However, much of the current information on human T-cell memory is based on analyzing circulating T cells. Here, we have studied the distribution and age-related changes of memory T-cell subsets in samples from blood, mesenteric LNs, spleen, and ileum, obtained from donors ranging in age from 5 days to 67 years of age. Our data show that the main reservoir of polyclonal naive cells is found in the LNs, and the resting memory subsets capable of self-renewal are also prominent there. In contrast, nondividing but functionally active memory subsets dominate the spleen, and especially the ileum. In general, the replacement of naive cells with memory subsets continues throughout our period of observation, with no apparent plateau. In conclusion, the analysis of lymphoid and nonlymphoid tissues reveals a dynamic pattern of changes distinct to each tissue, and with substantial differences between CD4+ and CD8+ compartments.

AlkuperäiskieliEnglanti
Sivut882-894
JulkaisuEUROPEAN JOURNAL OF IMMUNOLOGY
Vuosikerta52
Numero6
Varhainen verkossa julkaisun päivämäärä30 maalisk. 2022
DOI - pysyväislinkit
TilaJulkaistu - kesäk. 2022
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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