Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Tutkijat

  • Mikko Konki
  • Maia Malonzo
  • Ida K. Karlsson
  • Noora Lindgren
  • Bishwa Ghimire
  • Johannes Smolander
  • Noora M. Scheinin
  • Miina Ollikainen
  • Asta Laiho
  • Laura L. Elo
  • Tapio Lonnberg
  • Matias Roytta
  • Nancy L. Pedersen
  • Jaakko Kaprio
  • Harri Lahdesmaki
  • Juha O. Rinne
  • Riikka J. Lund

Organisaatiot

  • Univ Turku, University of Turku, Turku Doctoral Programme Mol Med
  • Karolinska Inst, Karolinska Institutet, Dept Med Epidemiol & Biostat
  • Turku PET Centre
  • University of Helsinki
  • Turku Univ Hosp, University of Turku
  • Univ Turku, University of Turku, Turku Univ Hosp, Dept Pathol Neuropathol
  • Univ Southern Calif, University of Southern California, Dept Psychol
  • Turku Univ Hosp, University of Turku, Div Clin Neurosci
  • Åbo Akademi University

Kuvaus

Background Alzheimer's disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into the disease process would be highly valuable. Environmental and lifestyle factors largely modulate the disease risk and may influence the pathogenesis through epigenetic mechanisms, such as DNA methylation. As environmental and lifestyle factors may affect multiple tissues of the body, we hypothesized that the disease-associated DNA methylation signatures are detectable in the peripheral blood of discordant twin pairs. Results Comparison of 23 disease discordant Finnish twin pairs with reduced representation bisulfite sequencing revealed peripheral blood DNA methylation differences in 11 genomic regions with at least 15.0% median methylation difference and FDR adjusted p value

Yksityiskohdat

AlkuperäiskieliEnglanti
Artikkeli130
Sivumäärä12
JulkaisuClinical epigenetics
Vuosikerta11
Numero1
TilaJulkaistu - 2 syyskuuta 2019
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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