Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease

Mikko Konki; Maia Malonzo; Ida K. Karlsson; Noora Lindgren; Bishwa Ghimire; Johannes Smolander; Noora M. Scheinin; Miina Ollikainen; Asta Laiho; Laura L. Elo; Tapio Lonnberg; Matias Roytta; Nancy L. Pedersen; Jaakko Kaprio; Harri Lahdesmaki; Juha O. Rinne; Riikka J. Lund

doi:10.1186/s13148-019-0729-7

Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease

Mikko Konki, Maia Malonzo, Ida K. Karlsson, Noora Lindgren, Bishwa Ghimire, Johannes Smolander, Noora M. Scheinin, Miina Ollikainen, Asta Laiho, Laura L. Elo, Tapio Lonnberg, Matias Roytta, Nancy L. Pedersen, Jaakko Kaprio, Harri Lahdesmaki, Juha O. Rinne, Riikka J. Lund^*

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

31 Sitaatiot (Scopus)

101 Lataukset (Pure)

Abstrakti

Background Alzheimer's disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into the disease process would be highly valuable. Environmental and lifestyle factors largely modulate the disease risk and may influence the pathogenesis through epigenetic mechanisms, such as DNA methylation. As environmental and lifestyle factors may affect multiple tissues of the body, we hypothesized that the disease-associated DNA methylation signatures are detectable in the peripheral blood of discordant twin pairs. Results Comparison of 23 disease discordant Finnish twin pairs with reduced representation bisulfite sequencing revealed peripheral blood DNA methylation differences in 11 genomic regions with at least 15.0% median methylation difference and FDR adjusted p value

Alkuperäiskieli	Englanti
Artikkeli	130
Sivumäärä	12
Julkaisu	Clinical Epigenetics
Vuosikerta	11
Numero	1
DOI - pysyväislinkit	https://doi.org/10.1186/s13148-019-0729-7
Tila	Julkaistu - 2 syysk. 2019
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Pääsy asiakirjaan

10.1186/s13148-019-0729-7

s13148-019-0729-7Final published version, 1,24 MBLisenssi: CC BY

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Konki, M., Malonzo, M., Karlsson, I. K., Lindgren, N., Ghimire, B., Smolander, J., Scheinin, N. M., Ollikainen, M., Laiho, A., Elo, L. L., Lonnberg, T., Roytta, M., Pedersen, N. L., Kaprio, J., Lahdesmaki, H., Rinne, J. O., & Lund, R. J. (2019). Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease. Clinical Epigenetics, 11(1), Artikkeli 130. https://doi.org/10.1186/s13148-019-0729-7

@article{5d60262a9df248ab808ef6ee1ce28ae6,

title = "Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease",

abstract = "Background Alzheimer's disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into the disease process would be highly valuable. Environmental and lifestyle factors largely modulate the disease risk and may influence the pathogenesis through epigenetic mechanisms, such as DNA methylation. As environmental and lifestyle factors may affect multiple tissues of the body, we hypothesized that the disease-associated DNA methylation signatures are detectable in the peripheral blood of discordant twin pairs. Results Comparison of 23 disease discordant Finnish twin pairs with reduced representation bisulfite sequencing revealed peripheral blood DNA methylation differences in 11 genomic regions with at least 15.0% median methylation difference and FDR adjusted p value",

keywords = "Alzheimer's disease, DNA methylome, Hippocampus, Peripheral blood, Twin pair, CEREBRAL GLUCOSE-METABOLISM, DEMENTIA, SUSCEPTIBILITY, REGISTRY, HISTORY, ADAR3, GENE, ANK1, PET",

author = "Mikko Konki and Maia Malonzo and Karlsson, {Ida K.} and Noora Lindgren and Bishwa Ghimire and Johannes Smolander and Scheinin, {Noora M.} and Miina Ollikainen and Asta Laiho and Elo, {Laura L.} and Tapio Lonnberg and Matias Roytta and Pedersen, {Nancy L.} and Jaakko Kaprio and Harri Lahdesmaki and Rinne, {Juha O.} and Lund, {Riikka J.}",

year = "2019",

month = sep,

day = "2",

doi = "10.1186/s13148-019-0729-7",

language = "English",

volume = "11",

journal = "Clinical Epigenetics",

issn = "1868-7075",

publisher = "BioMed Central",

number = "1",

}

Konki, M, Malonzo, M, Karlsson, IK, Lindgren, N, Ghimire, B, Smolander, J, Scheinin, NM, Ollikainen, M, Laiho, A, Elo, LL, Lonnberg, T, Roytta, M, Pedersen, NL, Kaprio, J, Lahdesmaki, H, Rinne, JO & Lund, RJ 2019, 'Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease', Clinical Epigenetics, Vuosikerta 11, Nro 1, 130. https://doi.org/10.1186/s13148-019-0729-7

TY - JOUR

T1 - Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease

AU - Konki, Mikko

AU - Malonzo, Maia

AU - Karlsson, Ida K.

AU - Lindgren, Noora

AU - Ghimire, Bishwa

AU - Smolander, Johannes

AU - Scheinin, Noora M.

AU - Ollikainen, Miina

AU - Laiho, Asta

AU - Elo, Laura L.

AU - Lonnberg, Tapio

AU - Roytta, Matias

AU - Pedersen, Nancy L.

AU - Kaprio, Jaakko

AU - Lahdesmaki, Harri

AU - Rinne, Juha O.

AU - Lund, Riikka J.

PY - 2019/9/2

Y1 - 2019/9/2

N2 - Background Alzheimer's disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into the disease process would be highly valuable. Environmental and lifestyle factors largely modulate the disease risk and may influence the pathogenesis through epigenetic mechanisms, such as DNA methylation. As environmental and lifestyle factors may affect multiple tissues of the body, we hypothesized that the disease-associated DNA methylation signatures are detectable in the peripheral blood of discordant twin pairs. Results Comparison of 23 disease discordant Finnish twin pairs with reduced representation bisulfite sequencing revealed peripheral blood DNA methylation differences in 11 genomic regions with at least 15.0% median methylation difference and FDR adjusted p value

AB - Background Alzheimer's disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into the disease process would be highly valuable. Environmental and lifestyle factors largely modulate the disease risk and may influence the pathogenesis through epigenetic mechanisms, such as DNA methylation. As environmental and lifestyle factors may affect multiple tissues of the body, we hypothesized that the disease-associated DNA methylation signatures are detectable in the peripheral blood of discordant twin pairs. Results Comparison of 23 disease discordant Finnish twin pairs with reduced representation bisulfite sequencing revealed peripheral blood DNA methylation differences in 11 genomic regions with at least 15.0% median methylation difference and FDR adjusted p value

KW - Alzheimer's disease

KW - DNA methylome

KW - Hippocampus

KW - Peripheral blood

KW - Twin pair

KW - CEREBRAL GLUCOSE-METABOLISM

KW - DEMENTIA

KW - SUSCEPTIBILITY

KW - REGISTRY

KW - HISTORY

KW - ADAR3

KW - GENE

KW - ANK1

KW - PET

U2 - 10.1186/s13148-019-0729-7

DO - 10.1186/s13148-019-0729-7

M3 - Article

C2 - 31477183

SN - 1868-7075

VL - 11

JO - Clinical Epigenetics

JF - Clinical Epigenetics

IS - 1

M1 - 130

ER -

Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease

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