Optimization of an NLEO-based algorithm for automated detection of spontaneous activity transients in early preterm EEG

We propose here a simple algorithm for automated detection of spontaneous activity transients (SATs) in early preterm electroencephalography (EEG). The parameters of the algorithm were optimized by supervised learning using a gold standard created from visual classification data obtained from three human raters. The generalization performance of the algorithm was estimated by leaveone-out cross-validation. The mean sensitivity of the optimized algorithm was 97% (range 91-100%) and specificity 95% (76-100%). The optimized algorithm makes it possible to systematically study brain state fluctuations of preterm infants.