On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipient

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On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipient. / Ridgway, Cathy; Bawuah, Prince; Markl, Daniel ; Zeitler, J. Axel; Ketolainen, Jarkko; Peiponen, Kai-Erik; Gane, Patrick.

julkaisussa: International Journal of Pharmaceutics, Vuosikerta 526, Nro 1-2, 30.06.2017, s. 321-331.

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

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Ridgway, Cathy ; Bawuah, Prince ; Markl, Daniel ; Zeitler, J. Axel ; Ketolainen, Jarkko ; Peiponen, Kai-Erik ; Gane, Patrick. / On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipient. Julkaisussa: International Journal of Pharmaceutics. 2017 ; Vuosikerta 526, Nro 1-2. Sivut 321-331.

Bibtex - Lataa

@article{1d35e202e6634db58e04c952643e2591,
title = "On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipient",
abstract = "The physical properties and mechanical integrity of pharmaceutical tablets are of major importance when loading with active pharmaceutical ingredient(s) (API) in order to ensure ease of processing, control of dosage and stability during transportation and handling prior to patient consumption. The interaction between API and excipient, acting as functional extender and binder, however, is little understood in this context. The API indomethacin is combined in this study with microcrystalline cellulose (MCC) at increasing loading levels. Tablets from the defined API/MCC ratios are made under conditions of controlled porosity and tablet thickness, resulting from different compression conditions, and thus compaction levels. Mercury intrusion porosimetry is used to establish the accessible pore volume, pore size distribution and, adopting the observed region of elastic intrusion-extrusion at high pressure, an elastic bulk modulus of the skeletal material is recorded. Porosity values are compared to previously published values derived from terahertz (THz) refractive index data obtained from exactly the same tablet sample sets. It is shown that the elastic bulk modulus is dependent on API wt{\%} loading under constant tablet preparation conditions delivering equal dimensions and porosity. The findings are considered of novel value in respect to establishing consistency of tablet production and optimisation of physical properties.",
keywords = "API impact on tablet structure, Excipient-API interactions, Mechanical properties of compacts, Pharmaceutical tableting, Pore network analysis, Tablet porosity, Terahertz measurements",
author = "Cathy Ridgway and Prince Bawuah and Daniel Markl and Zeitler, {J. Axel} and Jarkko Ketolainen and Kai-Erik Peiponen and Patrick Gane",
year = "2017",
month = "6",
day = "30",
doi = "10.1016/j.ijpharm.2017.04.038",
language = "English",
volume = "526",
pages = "321--331",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS - Lataa

TY - JOUR

T1 - On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipient

AU - Ridgway, Cathy

AU - Bawuah, Prince

AU - Markl, Daniel

AU - Zeitler, J. Axel

AU - Ketolainen, Jarkko

AU - Peiponen, Kai-Erik

AU - Gane, Patrick

PY - 2017/6/30

Y1 - 2017/6/30

N2 - The physical properties and mechanical integrity of pharmaceutical tablets are of major importance when loading with active pharmaceutical ingredient(s) (API) in order to ensure ease of processing, control of dosage and stability during transportation and handling prior to patient consumption. The interaction between API and excipient, acting as functional extender and binder, however, is little understood in this context. The API indomethacin is combined in this study with microcrystalline cellulose (MCC) at increasing loading levels. Tablets from the defined API/MCC ratios are made under conditions of controlled porosity and tablet thickness, resulting from different compression conditions, and thus compaction levels. Mercury intrusion porosimetry is used to establish the accessible pore volume, pore size distribution and, adopting the observed region of elastic intrusion-extrusion at high pressure, an elastic bulk modulus of the skeletal material is recorded. Porosity values are compared to previously published values derived from terahertz (THz) refractive index data obtained from exactly the same tablet sample sets. It is shown that the elastic bulk modulus is dependent on API wt% loading under constant tablet preparation conditions delivering equal dimensions and porosity. The findings are considered of novel value in respect to establishing consistency of tablet production and optimisation of physical properties.

AB - The physical properties and mechanical integrity of pharmaceutical tablets are of major importance when loading with active pharmaceutical ingredient(s) (API) in order to ensure ease of processing, control of dosage and stability during transportation and handling prior to patient consumption. The interaction between API and excipient, acting as functional extender and binder, however, is little understood in this context. The API indomethacin is combined in this study with microcrystalline cellulose (MCC) at increasing loading levels. Tablets from the defined API/MCC ratios are made under conditions of controlled porosity and tablet thickness, resulting from different compression conditions, and thus compaction levels. Mercury intrusion porosimetry is used to establish the accessible pore volume, pore size distribution and, adopting the observed region of elastic intrusion-extrusion at high pressure, an elastic bulk modulus of the skeletal material is recorded. Porosity values are compared to previously published values derived from terahertz (THz) refractive index data obtained from exactly the same tablet sample sets. It is shown that the elastic bulk modulus is dependent on API wt% loading under constant tablet preparation conditions delivering equal dimensions and porosity. The findings are considered of novel value in respect to establishing consistency of tablet production and optimisation of physical properties.

KW - API impact on tablet structure

KW - Excipient-API interactions

KW - Mechanical properties of compacts

KW - Pharmaceutical tableting

KW - Pore network analysis

KW - Tablet porosity

KW - Terahertz measurements

UR - http://www.scopus.com/inward/record.url?scp=85019224122&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2017.04.038

DO - 10.1016/j.ijpharm.2017.04.038

M3 - Article

VL - 526

SP - 321

EP - 331

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 13368226