TY - JOUR
T1 - Neurotoxicity of pesticides – A link to neurodegeneration
AU - Vellingiri, Balachandar
AU - Chandrasekhar, Mamatha
AU - Sri Sabari, S.
AU - Gopalakrishnan, Abilash Valsala
AU - Narayanasamy, Arul
AU - Venkatesan, Dhivya
AU - Iyer, Mahalaxmi
AU - Kesari, Kavindra
AU - Dey, Abhijit
N1 - Funding Information:
The author Dr. VB would like to thank Bharathiar University for providing the necessary infrastructure facility and the Indian Council of Medical Research DHR-GIA [grant number: GIA/2019/000276/PRCGIA], Government of India, New Delhi for providing necessary help in carrying out this review process.
Funding Information:
This work was supported by the Indian Council of Medical Research DHR-GIA [grant number: GIA/2019/000276/PRCGIA ], and by the Department of Applied Physics, School of Science, Aalto University , Espoo, Finland. Government of India.
Publisher Copyright:
© 2022
PY - 2022/9/15
Y1 - 2022/9/15
N2 - Parkinson's disease (PD) is a neurodegenerative disorder which mainly targets motor symptoms such as tremor, rigidity, bradykinesia and postural instability. The physiological changes occur due to dopamine depletion in basal ganglia region of the brain. PD aetiology is not yet elucidated clearly but genetic and environmental factors play a prominent role in disease occurrence. Despite of various environmental factors, pesticides exposure has been convicted as major candidate in PD pathogenesis. Among various pesticides 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been widely investigated in PD following with paraquat (PQ), maneb (MB), organochlorines (OC) and rotenone. Effect of these pesticides has been suggested to be involved in oxidative stress, alterations in dopamine transporters, mitochondrial dysfunction, α-synuclein (αSyn) fibrillation, and neuroinflammation in PD. The present review discusses the influence of pesticides in neurodegeneration and its related epidemiological studies conducted in PD. Furthermore, we have deliberated the common pesticides involved in PD and its associated genetic alterations and the probable mechanism of them behind PD pathogenesis. Hence, we conclude that pesticides play a prominent role in PD pathogenesis and advance research is needed to investigate the alterations in genetic and mechanistic aspects of PD.
AB - Parkinson's disease (PD) is a neurodegenerative disorder which mainly targets motor symptoms such as tremor, rigidity, bradykinesia and postural instability. The physiological changes occur due to dopamine depletion in basal ganglia region of the brain. PD aetiology is not yet elucidated clearly but genetic and environmental factors play a prominent role in disease occurrence. Despite of various environmental factors, pesticides exposure has been convicted as major candidate in PD pathogenesis. Among various pesticides 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been widely investigated in PD following with paraquat (PQ), maneb (MB), organochlorines (OC) and rotenone. Effect of these pesticides has been suggested to be involved in oxidative stress, alterations in dopamine transporters, mitochondrial dysfunction, α-synuclein (αSyn) fibrillation, and neuroinflammation in PD. The present review discusses the influence of pesticides in neurodegeneration and its related epidemiological studies conducted in PD. Furthermore, we have deliberated the common pesticides involved in PD and its associated genetic alterations and the probable mechanism of them behind PD pathogenesis. Hence, we conclude that pesticides play a prominent role in PD pathogenesis and advance research is needed to investigate the alterations in genetic and mechanistic aspects of PD.
KW - Parkinson's disease (PD)
KW - Pesticide toxicology
KW - Pesticides
KW - Residual toxicant
KW - Toxic pollutant
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=85136312249&partnerID=8YFLogxK
U2 - 10.1016/j.ecoenv.2022.113972
DO - 10.1016/j.ecoenv.2022.113972
M3 - Review Article
AN - SCOPUS:85136312249
SN - 0147-6513
VL - 243
SP - 1
EP - 11
JO - Ecotoxicology and Environmental Safety
JF - Ecotoxicology and Environmental Safety
M1 - 113972
ER -
