Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration

Tutkimustuotos: Lehtiartikkeli


  • Filipe Ferreira
  • Lucas P. Souza
  • Thais M. M. Martins
  • Joao H. Lopes
  • Bruno Dufau Mattos

  • Marcos Mariano
  • Ivanei F. Pinheiro
  • Thalita M. Valverde
  • Sebastien Livi
  • Jose A. Camilli
  • Alfredo M. Goes
  • Rubia F. Gouveia
  • Liliane M. F. Lona
  • Orlando Rojas Gaona


  • Fed Univ Minas Gerais UFMG, Universidade Federal de Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol
  • University of Campinas
  • Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970 Campinas-SP, Brazil
  • Université de Lyon
  • Federal University of Minas Gerais (UFMG), 31270-901 Belo Horizonte-MG
  • Technological Institute of Aeronautics (ITA), 12228-900 Sao Jose dos Campos-SP
  • Federal University of Minas Gerais, (UFMG), 31270-901 Belo Horizonte-MG
  • Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Nanotechnol Natl Lab LNNano


A major challenge exists in the preparation of scaffolds for bone regeneration, namely, achieving simultaneously bioactivity, biocompatibility, mechanical performance and simple manufacturing. Here, cellulose nanofibrils (CNF) are introduced for the preparation of scaffolds taking advantage of their biocompatibility and ability to form strong 3D porous networks from aqueous suspensions. CNF are made bioactive for bone formation through a simple and scalable strategy that achieves highly interconnected 3D networks. The resultant materials optimally combine morphological and mechanical features and facilitate hydroxyapatite formation while releasing essential ions for in vivo bone repair. The porosity and roughness of the scaffolds favor several cell functions while the ions act in the expression of genes associated with cell differentiation. Ion release is found critical to enhance the production of the bone morphogenetic protein 2 (BMP-2) from cells within the fractured area, thus accelerating the in vivo bone repair. Systemic biocompatibility indicates no negative effects on vital organs such as the liver and kidneys. The results pave the way towards a facile preparation of advanced, high performance CNF-based scaffolds for bone tissue engineering.


TilaJulkaistu - 14 marraskuuta 2019
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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