Multifunctional 3D-Printed Patches for Long-Term Drug Release Therapies after Myocardial Infarction

Rubina Ajdary, Nazanin Zanjanizadeh Ezazi, Alexandra Correia, Marianna Kemell, Siqi Huan, Heikki J. Ruskoaho, Jouni Hirvonen, Hélder A. Santos, Orlando J. Rojas*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

14 Sitaatiot (Scopus)
12 Lataukset (Pure)

Abstrakti

A biomaterial system incorporating nanocellulose, poly(glycerol sebacate), and polypyrrole is introduced for the treatment of myocardial infarction. Direct ink writing of the multicomponent aqueous suspensions allows multifunctional lattice structures that not only feature elasticity and electrical conductivity but enable cell growth. They are proposed as cardiac patches given their biocompatibility with H9c2 cardiomyoblasts, which attach extensively at the microstructural level, and induce their proliferation for 28 days. Two model drugs (3i-1000 and curcumin) are investigated for their integration in the patches, either by loading in the precursor suspension used for extrusion or by direct impregnation of the as-obtained, dry lattice. In studies of drug release conducted for five months, a slow in vitro degradation of the cardiac patches is observed, which prevents drug burst release and indicates their suitability for long-term therapy. The combination of biocompatibility, biodegradability, mechanical strength, flexibility, and electrical conductivity fulfills the requirement of the highly dynamic and functional electroresponsive cardiac tissue. Overall, the proposed cardiac patches are viable alternatives for the regeneration of myocardium after infarction through the effective integration of cardiac cells with the biomaterial.

AlkuperäiskieliEnglanti
Artikkeli2003440
Sivumäärä10
JulkaisuAdvanced Functional Materials
Vuosikerta30
Numero34
Varhainen verkossa julkaisun päivämäärä1 heinäkuuta 2020
DOI - pysyväislinkit
TilaJulkaistu - 1 elokuuta 2020
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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