Molecular mechanisms of interplay between autophagy and metabolism in cancer

Sibi Raj, Vaishali Chandel, Arun Kumar, Kavindra Kesari, Shailendra Asthana, Janne Ruokolainen, Mohammad Amjad Kamal, Dhruv Kumar*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

5 Sitaatiot (Scopus)

Abstrakti

Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how autophagy and cancer cells go hand in hand to support cancer cell progression. The important aspect in cancer and autophagy is the interdependence of autophagy in the survival and progression of cancer cells. Autophagy is known to be a major cause of chemotherapeutic resistance in various cancer cell types. Therefore, inhibition of autophagy as an effective therapeutic approach is being actively studied and tested in clinical studies. Multiple metabolic pathways are linked with autophagy that could potentially be a significant target for chemotherapeutic strategy. The comprehension of the interconnection of autophagy with cancer metabolism can pave a novel findings for effective combinatorial therapeutic strategies.
AlkuperäiskieliEnglanti
Artikkeli118184
Sivut1-10
Sivumäärä10
JulkaisuLIFE SCIENCES
Vuosikerta259
DOI - pysyväislinkit
TilaJulkaistu - 15 lokak. 2020
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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