Molecular Conformer Search with Low-Energy Latent Space

Xiaomi Guo, Lincan Fang, Yong Xu, Wenhui Duan, Patrick Rinke, Milica Todorović, Xi Chen*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

12 Lataukset (Pure)

Abstrakti

Identifying low-energy conformers with quantum mechanical accuracy for molecules with many degrees of freedom is challenging. In this work, we use the molecular dihedral angles as features and explore the possibility of performing molecular conformer search in a latent space with a generative model named variational auto-encoder (VAE). We bias the VAE towards low-energy molecular configurations to generate more informative data. In this way, we can effectively build a reliable energy model for the low-energy potential energy surface. After the energy model has been built, we extract local-minimum conformations and refine them with structure optimization. We have tested and benchmarked our low-energy latent-space (LOLS) structure search method on organic molecules with 5-9 searching dimensions. Our results agree with previous studies.

AlkuperäiskieliEnglanti
Sivut4574−4585
JulkaisuJournal of Chemical Theory and Computation
Vuosikerta18
Numero7
DOI - pysyväislinkit
TilaJulkaistu - 12 heinäk. 2022
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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