Microfluidic immobilized enzyme reactors for prediction of drug clearance in VIVO

Iiro Kiiski; Sanna Artes; Ville Jokinen; Päivi Järvinen; Tiina Sikanen

Microfluidic immobilized enzyme reactors for prediction of drug clearance in VIVO

Iiro Kiiski^*, Sanna Artes, Ville Jokinen, Päivi Järvinen, Tiina Sikanen

^*Tämän työn vastaava kirjoittaja

Kemian ja materiaalitieteen laitos

University of Helsinki

Tutkimustuotos: Artikkeli kirjassa/konferenssijulkaisussa › Abstract › Scientific › vertaisarvioitu

Abstrakti

We describe a microfluidic immobilized enzyme reactor that facilitates the screening of complex drug-drug interactions involving several different drug-metabolizing enzymes, and thus offers a comprehensive tool for in vitro prediction of a drug's metabolic clearance in vivo.

Alkuperäiskieli	Englanti
Sivut	744-745
Sivumäärä	2
Tila	Julkaistu - 2019
OKM-julkaisutyyppi	Ei sovellu
Tapahtuma	International Conference on Miniaturized Systems for Chemistry and Life Sciences - Basel, Sveitsi Kesto: 27 lokak. 2019 → 31 lokak. 2019 Konferenssinumero: 23

Conference

Conference	International Conference on Miniaturized Systems for Chemistry and Life Sciences
Lyhennettä	MicroTAS
Maa/Alue	Sveitsi
Kaupunki	Basel
Ajanjakso	27/10/2019 → 31/10/2019

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Link to publication in Scopus

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@conference{bd8fa23cfe304089b293d2c7801aabde,

title = "Microfluidic immobilized enzyme reactors for prediction of drug clearance in VIVO",

abstract = "We describe a microfluidic immobilized enzyme reactor that facilitates the screening of complex drug-drug interactions involving several different drug-metabolizing enzymes, and thus offers a comprehensive tool for in vitro prediction of a drug's metabolic clearance in vivo.",

keywords = "Drug metabolism, Drug screening, Enzyme immobilization, Microreactors",

author = "Iiro Kiiski and Sanna Artes and Ville Jokinen and P{\"a}ivi J{\"a}rvinen and Tiina Sikanen",

year = "2019",

language = "English",

pages = "744--745",

note = "International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS ; Conference date: 27-10-2019 Through 31-10-2019",

}

Microfluidic immobilized enzyme reactors for prediction of drug clearance in VIVO. / Kiiski, Iiro; Artes, Sanna; Jokinen, Ville et al.
2019. 744-745 Abstraktin lähde: International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Sveitsi.

Tutkimustuotos: Artikkeli kirjassa/konferenssijulkaisussa › Abstract › Scientific › vertaisarvioitu

TY - CONF

T1 - Microfluidic immobilized enzyme reactors for prediction of drug clearance in VIVO

AU - Kiiski, Iiro

AU - Artes, Sanna

AU - Jokinen, Ville

AU - Järvinen, Päivi

AU - Sikanen, Tiina

N1 - Conference code: 23

PY - 2019

Y1 - 2019

N2 - We describe a microfluidic immobilized enzyme reactor that facilitates the screening of complex drug-drug interactions involving several different drug-metabolizing enzymes, and thus offers a comprehensive tool for in vitro prediction of a drug's metabolic clearance in vivo.

AB - We describe a microfluidic immobilized enzyme reactor that facilitates the screening of complex drug-drug interactions involving several different drug-metabolizing enzymes, and thus offers a comprehensive tool for in vitro prediction of a drug's metabolic clearance in vivo.

KW - Drug metabolism

KW - Drug screening

KW - Enzyme immobilization

KW - Microreactors

UR - http://www.scopus.com/inward/record.url?scp=85094942018&partnerID=8YFLogxK

M3 - Abstract

AN - SCOPUS:85094942018

SP - 744

EP - 745

T2 - International Conference on Miniaturized Systems for Chemistry and Life Sciences

Y2 - 27 October 2019 through 31 October 2019

ER -

Microfluidic immobilized enzyme reactors for prediction of drug clearance in VIVO

Abstrakti

Conference

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