Microfibers synthesized by wet-spinning of chitin nanomaterials : Mechanical, structural and cell proliferation properties

Ling Wang, Nazanin Zanjanizadeh Ezazi, Liang Liu, Rubina Ajdary, Wenchao Xiang, Maryam Borghei, Helder A. Santos, Orlando J. Rojas*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticle

42 Lataukset (Pure)

Abstrakti

Partially deacetylated chitin nanofibers (ChNF) were isolated from shell residues derived from crab biomass and used to prepare hydrogels, which were easily transformed into continuous microfibers by wet-spinning. We investigated the effect of ChNF solid content, extrusion rate and coagulant type, which included organic (acetone) and alkaline (NaOH and ammonia) solutions, on wet spinning. The properties of the microfibers and associated phenomena were assessed by tensile strength, quartz crystal microgravimetry, dynamic vapor sorption (DVS), thermogravimetric analysis and wide-angle X-ray scattering (WAXS). The as-spun microfibers (14 GPa stiffness) comprised hierarchical structures with fibrils aligned in the lateral direction. The microfibers exhibited a remarkable water sorption capacity (up to 22 g g(-1)), while being stable in the wet state (50% of dry strength), which warrants consideration as biobased absorbent systems. In addition, according to cell proliferation and viability of rat cardiac myoblast H9c2 and mouse bone osteoblast K7M2, the wet-spun ChNF microfibers showed excellent results and can be considered as fully safe for biomedical uses, such as in sutures, wound healing patches and cell culturing.

AlkuperäiskieliEnglanti
Sivut29450-29459
Sivumäärä10
JulkaisuRSC Advances
Vuosikerta10
Numero49
DOI - pysyväislinkit
TilaJulkaistu - 11 elokuuta 2020
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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