Metabolic regulation in progression to autoimmune diabetes

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Standard

Metabolic regulation in progression to autoimmune diabetes. / Sysi-Aho, Marko; Ermolov, Andrey; Gopalacharyulu, Peddinti V.; Tripathi, Abhishek; Seppänen-Laakso, Tuulikki; Maukonen, Johanna; Mattila, Ismo; Ruohonen, Suvi T.; Vähätalo, Laura; Yetukuri, Laxman; Härkönen, Taina; Lindfors, Erno; Nikkilä, Janne; Ilonen, Jorma; Simell, Olli; Saarela, Maria; Knip, Mikael; Kaski, Samuel; Savontaus, Eriika; Oresic, Matej.

julkaisussa: PLoS computational biology, Vuosikerta 7, Nro 10, e1002257, 2011, s. 1-16.

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Harvard

Sysi-Aho, M, Ermolov, A, Gopalacharyulu, PV, Tripathi, A, Seppänen-Laakso, T, Maukonen, J, Mattila, I, Ruohonen, ST, Vähätalo, L, Yetukuri, L, Härkönen, T, Lindfors, E, Nikkilä, J, Ilonen, J, Simell, O, Saarela, M, Knip, M, Kaski, S, Savontaus, E & Oresic, M 2011, 'Metabolic regulation in progression to autoimmune diabetes' PLoS computational biology, Vuosikerta. 7, Nro 10, e1002257, Sivut 1-16. https://doi.org/10.1371/journal.pcbi.1002257

APA

Sysi-Aho, M., Ermolov, A., Gopalacharyulu, P. V., Tripathi, A., Seppänen-Laakso, T., Maukonen, J., ... Oresic, M. (2011). Metabolic regulation in progression to autoimmune diabetes. PLoS computational biology, 7(10), 1-16. [e1002257]. https://doi.org/10.1371/journal.pcbi.1002257

Vancouver

Sysi-Aho M, Ermolov A, Gopalacharyulu PV, Tripathi A, Seppänen-Laakso T, Maukonen J et al. Metabolic regulation in progression to autoimmune diabetes. PLoS computational biology. 2011;7(10):1-16. e1002257. https://doi.org/10.1371/journal.pcbi.1002257

Author

Sysi-Aho, Marko ; Ermolov, Andrey ; Gopalacharyulu, Peddinti V. ; Tripathi, Abhishek ; Seppänen-Laakso, Tuulikki ; Maukonen, Johanna ; Mattila, Ismo ; Ruohonen, Suvi T. ; Vähätalo, Laura ; Yetukuri, Laxman ; Härkönen, Taina ; Lindfors, Erno ; Nikkilä, Janne ; Ilonen, Jorma ; Simell, Olli ; Saarela, Maria ; Knip, Mikael ; Kaski, Samuel ; Savontaus, Eriika ; Oresic, Matej. / Metabolic regulation in progression to autoimmune diabetes. Julkaisussa: PLoS computational biology. 2011 ; Vuosikerta 7, Nro 10. Sivut 1-16.

Bibtex - Lataa

@article{a00dab3c4ce54a02ba18c54e36146e5d,
title = "Metabolic regulation in progression to autoimmune diabetes",
abstract = "Recent evidence from serum metabolomics indicates that specific metabolic disturbances precede β-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes. The mechanisms behind these disturbances are unknown. Here we show the specificity of the pre-autoimmune metabolic changes, as indicated by their conservation in a murine model of type 1 diabetes. We performed a study in non-obese prediabetic (NOD) mice which recapitulated the design of the human study and derived the metabolic states from longitudinal lipidomics data. We show that female NOD mice who later progress to autoimmune diabetes exhibit the same lipidomic pattern as prediabetic children. These metabolic changes are accompanied by enhanced glucose-stimulated insulin secretion, normoglycemia, upregulation of insulinotropic amino acids in islets, elevated plasma leptin and adiponectin, and diminished gut microbial diversity of the Clostridium leptum group. Together, the findings indicate that autoimmune diabetes is preceded by a state of increased metabolic demands on the islets resulting in elevated insulin secretion and suggest alternative metabolic related pathways as therapeutic targets to prevent diabetes.",
author = "Marko Sysi-Aho and Andrey Ermolov and Gopalacharyulu, {Peddinti V.} and Abhishek Tripathi and Tuulikki Sepp{\"a}nen-Laakso and Johanna Maukonen and Ismo Mattila and Ruohonen, {Suvi T.} and Laura V{\"a}h{\"a}talo and Laxman Yetukuri and Taina H{\"a}rk{\"o}nen and Erno Lindfors and Janne Nikkil{\"a} and Jorma Ilonen and Olli Simell and Maria Saarela and Mikael Knip and Samuel Kaski and Eriika Savontaus and Matej Oresic",
note = "VK: airc hiit",
year = "2011",
doi = "10.1371/journal.pcbi.1002257",
language = "English",
volume = "7",
pages = "1--16",
journal = "PLoS computational biology",
issn = "1553-734X",
publisher = "Public Library of Science",
number = "10",

}

RIS - Lataa

TY - JOUR

T1 - Metabolic regulation in progression to autoimmune diabetes

AU - Sysi-Aho, Marko

AU - Ermolov, Andrey

AU - Gopalacharyulu, Peddinti V.

AU - Tripathi, Abhishek

AU - Seppänen-Laakso, Tuulikki

AU - Maukonen, Johanna

AU - Mattila, Ismo

AU - Ruohonen, Suvi T.

AU - Vähätalo, Laura

AU - Yetukuri, Laxman

AU - Härkönen, Taina

AU - Lindfors, Erno

AU - Nikkilä, Janne

AU - Ilonen, Jorma

AU - Simell, Olli

AU - Saarela, Maria

AU - Knip, Mikael

AU - Kaski, Samuel

AU - Savontaus, Eriika

AU - Oresic, Matej

N1 - VK: airc hiit

PY - 2011

Y1 - 2011

N2 - Recent evidence from serum metabolomics indicates that specific metabolic disturbances precede β-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes. The mechanisms behind these disturbances are unknown. Here we show the specificity of the pre-autoimmune metabolic changes, as indicated by their conservation in a murine model of type 1 diabetes. We performed a study in non-obese prediabetic (NOD) mice which recapitulated the design of the human study and derived the metabolic states from longitudinal lipidomics data. We show that female NOD mice who later progress to autoimmune diabetes exhibit the same lipidomic pattern as prediabetic children. These metabolic changes are accompanied by enhanced glucose-stimulated insulin secretion, normoglycemia, upregulation of insulinotropic amino acids in islets, elevated plasma leptin and adiponectin, and diminished gut microbial diversity of the Clostridium leptum group. Together, the findings indicate that autoimmune diabetes is preceded by a state of increased metabolic demands on the islets resulting in elevated insulin secretion and suggest alternative metabolic related pathways as therapeutic targets to prevent diabetes.

AB - Recent evidence from serum metabolomics indicates that specific metabolic disturbances precede β-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes. The mechanisms behind these disturbances are unknown. Here we show the specificity of the pre-autoimmune metabolic changes, as indicated by their conservation in a murine model of type 1 diabetes. We performed a study in non-obese prediabetic (NOD) mice which recapitulated the design of the human study and derived the metabolic states from longitudinal lipidomics data. We show that female NOD mice who later progress to autoimmune diabetes exhibit the same lipidomic pattern as prediabetic children. These metabolic changes are accompanied by enhanced glucose-stimulated insulin secretion, normoglycemia, upregulation of insulinotropic amino acids in islets, elevated plasma leptin and adiponectin, and diminished gut microbial diversity of the Clostridium leptum group. Together, the findings indicate that autoimmune diabetes is preceded by a state of increased metabolic demands on the islets resulting in elevated insulin secretion and suggest alternative metabolic related pathways as therapeutic targets to prevent diabetes.

UR - http://dx.doi.org/10.1371/journal.pcbi.1002257

U2 - 10.1371/journal.pcbi.1002257

DO - 10.1371/journal.pcbi.1002257

M3 - Article

VL - 7

SP - 1

EP - 16

JO - PLoS computational biology

JF - PLoS computational biology

SN - 1553-734X

IS - 10

M1 - e1002257

ER -

ID: 792016