Mechanical stimulation devices for mechanobiology studies: a market, literature, and patents review

F. Melo-Fonseca*, O. Carvalho, M. Gasik, G. Miranda, F. S. Silva

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliReview Articlevertaisarvioitu

12 Sitaatiot (Scopus)
126 Lataukset (Pure)

Abstrakti

Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human body. To more closely mimic the complex physiological environment, research has moved from two-dimensional (2D) culture systems to more sophisticated three-dimensional (3D) dynamic cultures. Unlike bioreactors or microfluidic-based culture models, cells are typically seeded on polymeric substrates or incorporated into 3D constructs which are mechanically stimulated to investigate cell response to mechanical stresses, such as tensile or compressive. This review focuses on the working principles of mechanical stimulation devices currently available on the market or custom-built by research groups or protected by patents and highlights the main features still open to improvement. These are the features which could be focused on to perform, in the future, more reliable and accurate mechanobiology studies. Graphic abstract: [Figure not available: see fulltext.].

AlkuperäiskieliEnglanti
Sivut340–371
JulkaisuBio-Design and Manufacturing
Vuosikerta6
Numero3
Varhainen verkossa julkaisun päivämäärä1 huhtik. 2023
DOI - pysyväislinkit
TilaJulkaistu - toukok. 2023
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

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