Left hemisphere enhancement of auditory activation in language impaired children

Tutkimustuotos: Lehtiartikkeli

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Left hemisphere enhancement of auditory activation in language impaired children. / van Bijnen, Sam; Kärkkäinen, Salme; Helenius, Päivi; Parviainen, Tiina.

julkaisussa: Scientific Reports, Vuosikerta 9, Nro 1, 9087, 01.12.2019, s. 1-11.

Tutkimustuotos: Lehtiartikkeli

Harvard

van Bijnen, S, Kärkkäinen, S, Helenius, P & Parviainen, T 2019, 'Left hemisphere enhancement of auditory activation in language impaired children', Scientific Reports, Vuosikerta. 9, Nro 1, 9087, Sivut 1-11. https://doi.org/10.1038/s41598-019-45597-y

APA

van Bijnen, S., Kärkkäinen, S., Helenius, P., & Parviainen, T. (2019). Left hemisphere enhancement of auditory activation in language impaired children. Scientific Reports, 9(1), 1-11. [9087]. https://doi.org/10.1038/s41598-019-45597-y

Vancouver

Author

van Bijnen, Sam ; Kärkkäinen, Salme ; Helenius, Päivi ; Parviainen, Tiina. / Left hemisphere enhancement of auditory activation in language impaired children. Julkaisussa: Scientific Reports. 2019 ; Vuosikerta 9, Nro 1. Sivut 1-11.

Bibtex - Lataa

@article{e92c12c7bf71406daf379465d02cf400,
title = "Left hemisphere enhancement of auditory activation in language impaired children",
abstract = "Specific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development.",
author = "{van Bijnen}, Sam and Salme K{\"a}rkk{\"a}inen and P{\"a}ivi Helenius and Tiina Parviainen",
note = "| openaire: EC/H2020/641652/EU//ChildBrain",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41598-019-45597-y",
language = "English",
volume = "9",
pages = "1--11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS - Lataa

TY - JOUR

T1 - Left hemisphere enhancement of auditory activation in language impaired children

AU - van Bijnen, Sam

AU - Kärkkäinen, Salme

AU - Helenius, Päivi

AU - Parviainen, Tiina

N1 - | openaire: EC/H2020/641652/EU//ChildBrain

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Specific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development.

AB - Specific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development.

UR - http://www.scopus.com/inward/record.url?scp=85067873473&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-45597-y

DO - 10.1038/s41598-019-45597-y

M3 - Article

VL - 9

SP - 1

EP - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 9087

ER -

ID: 35123415