Left hemisphere enhancement of auditory activation in language impaired children

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Tutkijat

  • Sam van Bijnen
  • Salme Kärkkäinen
  • Päivi Helenius
  • Tiina Parviainen

Organisaatiot

  • Nanoscience Center
  • University of Helsinki

Kuvaus

Specific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development.

Yksityiskohdat

AlkuperäiskieliEnglanti
Artikkeli9087
Sivut1-11
Sivumäärä11
JulkaisuScientific Reports
Vuosikerta9
Numero1
TilaJulkaistu - 1 joulukuuta 2019
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

ID: 35123415