Investigation of precise molecular mechanistic action of tobacco-associated carcinogen `NNK´ induced carcinogenesis: A system biology approach

Tutkimustuotos: Lehtiartikkeli

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Investigation of precise molecular mechanistic action of tobacco-associated carcinogen `NNK´ induced carcinogenesis : A system biology approach. / Anukriti; Dhasmana, Anupam; Uniyal, Swati; Somvanshi, Pallavi; Bhardwaj, Uma; Gupta, Meenu; Haque, Shafiul; Lohani, Mohtashim; Kumar, Dhruv; Ruokolainen, Janne; Kesari, Kavindra Kumar.

julkaisussa: Genes, Vuosikerta 10, Nro 8, 564, 01.08.2019, s. 1-22.

Tutkimustuotos: Lehtiartikkeli

Harvard

Anukriti, Dhasmana, A, Uniyal, S, Somvanshi, P, Bhardwaj, U, Gupta, M, Haque, S, Lohani, M, Kumar, D, Ruokolainen, J & Kesari, KK 2019, 'Investigation of precise molecular mechanistic action of tobacco-associated carcinogen `NNK´ induced carcinogenesis: A system biology approach', Genes, Vuosikerta. 10, Nro 8, 564, Sivut 1-22. https://doi.org/10.3390/genes10080564

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Author

Anukriti ; Dhasmana, Anupam ; Uniyal, Swati ; Somvanshi, Pallavi ; Bhardwaj, Uma ; Gupta, Meenu ; Haque, Shafiul ; Lohani, Mohtashim ; Kumar, Dhruv ; Ruokolainen, Janne ; Kesari, Kavindra Kumar. / Investigation of precise molecular mechanistic action of tobacco-associated carcinogen `NNK´ induced carcinogenesis : A system biology approach. Julkaisussa: Genes. 2019 ; Vuosikerta 10, Nro 8. Sivut 1-22.

Bibtex - Lataa

@article{0dad4cd2a6124690a5b5c8cdf4b66e82,
title = "Investigation of precise molecular mechanistic action of tobacco-associated carcinogen `NNK´ induced carcinogenesis: A system biology approach",
abstract = "Cancer is the second deadliest disease listed by the WHO. One of the major causes of cancer disease is tobacco and consumption possibly due to its main component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). A plethora of studies have been conducted in the past aiming to decipher the association of NNK with other diseases. However, it is strongly linked with cancer development. Despite these studies, a clear molecular mechanism and the impact of NNK on various system-level networks is not known. In the present study, system biology tools were employed to understand the key regulatory mechanisms and the perturbations that will happen in the cellular processes due to NNK. To investigate the system level influence of the carcinogen, NNK rewired protein–protein interaction network (PPIN) was generated from 544 reported proteins drawn out from 1317 articles retrieved from PubMed. The noise was removed from PPIN by the method of modulation. Gene ontology (GO) enrichment was performed on the seed proteins extracted from various modules to find the most affected pathways by the genes/proteins. For the modulation, Molecular COmplex DEtection (MCODE) was used to generate 19 modules containing 115 seed proteins. Further, scrutiny of the targeted biomolecules was done by the graph theory and molecular docking. GO enrichment analysis revealed that mostly cell cycle regulatory proteins were affected by NNK.",
keywords = "Cancer, Gene ontology, NNK, Protein, Protein interaction network, Systems biology, Topological analysis",
author = "Anukriti and Anupam Dhasmana and Swati Uniyal and Pallavi Somvanshi and Uma Bhardwaj and Meenu Gupta and Shafiul Haque and Mohtashim Lohani and Dhruv Kumar and Janne Ruokolainen and Kesari, {Kavindra Kumar}",
year = "2019",
month = "8",
day = "1",
doi = "10.3390/genes10080564",
language = "English",
volume = "10",
pages = "1--22",
journal = "Genes",
issn = "2073-4425",
publisher = "MDPI AG",
number = "8",

}

RIS - Lataa

TY - JOUR

T1 - Investigation of precise molecular mechanistic action of tobacco-associated carcinogen `NNK´ induced carcinogenesis

T2 - A system biology approach

AU - Anukriti,

AU - Dhasmana, Anupam

AU - Uniyal, Swati

AU - Somvanshi, Pallavi

AU - Bhardwaj, Uma

AU - Gupta, Meenu

AU - Haque, Shafiul

AU - Lohani, Mohtashim

AU - Kumar, Dhruv

AU - Ruokolainen, Janne

AU - Kesari, Kavindra Kumar

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Cancer is the second deadliest disease listed by the WHO. One of the major causes of cancer disease is tobacco and consumption possibly due to its main component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). A plethora of studies have been conducted in the past aiming to decipher the association of NNK with other diseases. However, it is strongly linked with cancer development. Despite these studies, a clear molecular mechanism and the impact of NNK on various system-level networks is not known. In the present study, system biology tools were employed to understand the key regulatory mechanisms and the perturbations that will happen in the cellular processes due to NNK. To investigate the system level influence of the carcinogen, NNK rewired protein–protein interaction network (PPIN) was generated from 544 reported proteins drawn out from 1317 articles retrieved from PubMed. The noise was removed from PPIN by the method of modulation. Gene ontology (GO) enrichment was performed on the seed proteins extracted from various modules to find the most affected pathways by the genes/proteins. For the modulation, Molecular COmplex DEtection (MCODE) was used to generate 19 modules containing 115 seed proteins. Further, scrutiny of the targeted biomolecules was done by the graph theory and molecular docking. GO enrichment analysis revealed that mostly cell cycle regulatory proteins were affected by NNK.

AB - Cancer is the second deadliest disease listed by the WHO. One of the major causes of cancer disease is tobacco and consumption possibly due to its main component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). A plethora of studies have been conducted in the past aiming to decipher the association of NNK with other diseases. However, it is strongly linked with cancer development. Despite these studies, a clear molecular mechanism and the impact of NNK on various system-level networks is not known. In the present study, system biology tools were employed to understand the key regulatory mechanisms and the perturbations that will happen in the cellular processes due to NNK. To investigate the system level influence of the carcinogen, NNK rewired protein–protein interaction network (PPIN) was generated from 544 reported proteins drawn out from 1317 articles retrieved from PubMed. The noise was removed from PPIN by the method of modulation. Gene ontology (GO) enrichment was performed on the seed proteins extracted from various modules to find the most affected pathways by the genes/proteins. For the modulation, Molecular COmplex DEtection (MCODE) was used to generate 19 modules containing 115 seed proteins. Further, scrutiny of the targeted biomolecules was done by the graph theory and molecular docking. GO enrichment analysis revealed that mostly cell cycle regulatory proteins were affected by NNK.

KW - Cancer

KW - Gene ontology

KW - NNK

KW - Protein

KW - Protein interaction network

KW - Systems biology

KW - Topological analysis

UR - http://www.scopus.com/inward/record.url?scp=85070642203&partnerID=8YFLogxK

U2 - 10.3390/genes10080564

DO - 10.3390/genes10080564

M3 - Article

VL - 10

SP - 1

EP - 22

JO - Genes

JF - Genes

SN - 2073-4425

IS - 8

M1 - 564

ER -

ID: 36258163