Integrating CRISPR/Cas systems with programmable DNA nanostructures for delivery and beyond

Petteri Piskunen, Rosalind Latham, Christopher E. West, Matteo Castronovo*, Veikko Linko*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliReview ArticleScientificvertaisarvioitu

3 Sitaatiot (Scopus)
3 Lataukset (Pure)

Abstrakti

Precise genome editing with CRISPR/Cas paves the way for many biochemical, biotechnological, and medical applications, and consequently, it may enable treatment of already known and still-to-be-found genetic diseases. Meanwhile, another rapidly emerging field—structural DNA nanotechnology—provides a customizable and modular platform for accurate positioning of nanoscopic materials, for e.g., biomedical uses. This addressability has just recently been applied in conjunction with the newly developed gene engineering tools to enable impactful, programmable nanotechnological applications. As of yet, self-assembled DNA nanostructures have been mainly employed to enhance and direct the delivery of CRISPR/Cas, but lately the groundwork has also been laid out for other intriguing and complex functions. These recent advances will be described in this perspective.

AlkuperäiskieliEnglanti
Artikkeli104389
Sivumäärä12
JulkaisuiScience
Vuosikerta25
Numero6
Varhainen verkossa julkaisun päivämäärä22 toukok. 2022
DOI - pysyväislinkit
TilaJulkaistu - 17 kesäk. 2022
OKM-julkaisutyyppiA2 Arvio tiedejulkaisuussa (artikkeli)

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