Insights into the evaporation kinetics of indomethacin solutions

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Tutkijat

Organisaatiot

  • University of Eastern Finland
  • Martin Luther University Halle-Wittenberg
  • Lappeenranta University of Technology
  • University of Turku

Kuvaus

Evaporation rates play a key role in evaporation crystallization and the drying of crystal products. Raman analysis was used to study the effect of the evaporation rate on the polymorphs of indomethacin at room temperature. The studied solvents were highly volatile ethanol, acetone, and ethyl acetate. The approach was based on a mass transfer model of evaporation, and experimental flux measurements were used for model evaluation. Evaporation rates from porous carriers were also investigated. The studied mesoporous silicon microparticles can be used in oral dosage forms of poorly soluble active pharmaceutical ingredients. Evaporation rates of dimethyl sulfoxide from a pure solvent, from indomethacin solutions, and from solutions containing microparticles were measured at 100°C. An evaporation rate model of porous particles was used and the predicted results were compared with the experimental results obtained.

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut1300-1306
Sivumäärä7
JulkaisuChemical Engineering and Technology
Vuosikerta36
Numero8
TilaJulkaistu - elokuuta 2013
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

ID: 3352365