Inhibition of human natural killer cell activity by cereulide, an emetic toxin from Bacillus cereus

A Paananen*, R Mikkola, T Sareneva, S Matikainen, M Hess, M Andersson, Petro Julkunen, MS Salkinoja-Salonen, T Timonen

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

Abstrakti

The lipophilic toxin, cereulide, emitted by emetic food poisoning causing strains of Bacillus cereus , is a powerful mitochondria toxin. It is highly lipophilic and rapidly absorbed from the gut into the bloodstream. We tested how this toxin influences natural killer (NK) cells, which are important effectors in defence against infections and malignancy. Cereulide inhibited cytotoxicity and cytokine production of natural killer cells, caused swelling of natural killer cell mitochondria, and eventually induced natural killer cell apoptosis. The suppressive effect on cytotoxicity was fast and toxic concentration low, 20-30 mug/l. As the emesis causing concentration of cereulide is around 10 mug/kg of total body mass, our results suggest that emesis causing or even lower doses of cereulide may also have a systemic natural killer cell suppressive effect.

AlkuperäiskieliEnglanti
Sivut420-428
Sivumäärä9
JulkaisuCLINICAL AND EXPERIMENTAL IMMUNOLOGY
Vuosikerta129
Numero3
TilaJulkaistu - syyskuuta 2002
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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