Projekteja vuodessa
Abstrakti
In transcranial magnetic stimulation (TMS), the initial cortical activation due to stimulation is determined by the state of the brain and the magnitude, waveform, and direction of the induced electric field (E-field) in the cortex. The E-field distribution depends on the conductivity geometry of the head. The effects of deviations from a spherically symmetric conductivity profile have been studied in detail in humans. In small mammals, such as rats, these effects are more pronounced due to their less spherical head, proportionally much thicker neck region, and overall much smaller size compared to the TMS coils. In this study, we describe a simple method for building individual realistically shaped head models for rats from high-resolution X-ray tomography images. We computed the TMS-induced E-field with the boundary element method and assessed the effect of head-model simplifications on the estimated E-field. The deviations from spherical symmetry have large, non-trivial effects on the E-field distribution: for some coil orientations, the strongest stimulation is in the brainstem even when the coil is over the motor cortex. With modelling prior to an experiment, such problematic coil orientations can be avoided for more accurate targeting.
Alkuperäiskieli | Englanti |
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Artikkeli | 17397 |
Sivumäärä | 10 |
Julkaisu | Scientific Reports |
Vuosikerta | 10 |
Numero | 1 |
DOI - pysyväislinkit | |
Tila | Julkaistu - 1 jouluk. 2020 |
OKM-julkaisutyyppi | A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä |
Sormenjälki
Sukella tutkimusaiheisiin 'Individual head models for estimating the TMS-induced electric field in rat brain'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.Projektit
- 2 Päättynyt
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Monikohteinen transkraniaalinen magneettistimulaatio
Nieminen, J. (Vastuullinen tutkija)
01/09/2016 → 31/08/2021
Projekti: Academy of Finland: Other research funding
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Aivojen mittaaminen, mallinnus ja modulointi
Ilmoniemi, R. (Vastuullinen tutkija)
01/01/2015 → 31/12/2016
Projekti: Academy of Finland: Other research funding