In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

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In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells. / Figueiredo, Patrícia; Lintinen, Kalle; Kiriazis, Alexandros; Hynninen, Ville; Liu, Zehua; Bauleth-Ramos, Tomás; Rahikkala, Antti; Correia, Alexandra; Kohout, Tomáš; Sarmento, Bruno; Yli-Kauhaluoma, Jari; Hirvonen, Jouni; Ikkala, Olli; Kostiainen, Mauri A.; Santos, Hélder A.

julkaisussa: Biomaterials, Vuosikerta 121, 01.03.2017, s. 97-108.

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

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Figueiredo, P, Lintinen, K, Kiriazis, A, Hynninen, V, Liu, Z, Bauleth-Ramos, T, Rahikkala, A, Correia, A, Kohout, T, Sarmento, B, Yli-Kauhaluoma, J, Hirvonen, J, Ikkala, O, Kostiainen, MA & Santos, HA 2017, 'In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells', Biomaterials, Vuosikerta. 121, Sivut 97-108. https://doi.org/10.1016/j.biomaterials.2016.12.034

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Figueiredo, Patrícia ; Lintinen, Kalle ; Kiriazis, Alexandros ; Hynninen, Ville ; Liu, Zehua ; Bauleth-Ramos, Tomás ; Rahikkala, Antti ; Correia, Alexandra ; Kohout, Tomáš ; Sarmento, Bruno ; Yli-Kauhaluoma, Jari ; Hirvonen, Jouni ; Ikkala, Olli ; Kostiainen, Mauri A. ; Santos, Hélder A. / In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells. Julkaisussa: Biomaterials. 2017 ; Vuosikerta 121. Sivut 97-108.

Bibtex - Lataa

@article{7696d4394f9c479a96ea1fb23dcb1118,
title = "In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells",
abstract = "Currently, nanosystems have been developed and applied as promising vehicles for different biomedical applications. We have developed three lignin nanoparticles (LNPs): pure lignin nanoparticles (pLNPs), iron(III)-complexed lignin nanoparticles (Fe-LNPs), and Fe3O4-infused lignin nanoparticles (Fe3O4-LNPs) with round shape, narrow size distribution, reduced polydispersity and good stability at pH 7.4. The LNPs showed low cytotoxicity in all the tested cell lines and hemolytic rates below 12{\%} after 12 h of incubation. Additionally, they induced hydrogen peroxide production in a small extent and time-dependent manner, and the interaction with the cells increased over time, exhibiting a dose-dependent cell uptake. Concerning the drug loading, pLNPs showed the capacity to efficiently load poorly water-soluble drugs and other cytotoxic agents, e.g. sorafenib and benzazulene (BZL), and improve their release profiles at pH 5.5 and 7.4 in a sustained manner. Furthermore, the BZL-pLNPs presented an enhanced antiproliferation effect in different cells compared to the pure BZL and showed a maximal inhibitory concentration ranging from 0.64 to 12.4 μM after 24 h incubation. Overall, LNPs are promising candidates for drug delivery applications, and the superparamagnetic behavior of Fe3O4-LNPs makes them promising for cancer therapy and diagnosis, such as magnetic targeting and magnetic resonance imaging.",
keywords = "Antiproliferation effect, Benzazulene, Biocompatibility, Cellular uptake, Drug loading, Lignin nanoparticles",
author = "Patr{\'i}cia Figueiredo and Kalle Lintinen and Alexandros Kiriazis and Ville Hynninen and Zehua Liu and Tom{\'a}s Bauleth-Ramos and Antti Rahikkala and Alexandra Correia and Tom{\'a}š Kohout and Bruno Sarmento and Jari Yli-Kauhaluoma and Jouni Hirvonen and Olli Ikkala and Kostiainen, {Mauri A.} and Santos, {H{\'e}lder A.}",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.biomaterials.2016.12.034",
language = "English",
volume = "121",
pages = "97--108",
journal = "Biomaterials",
issn = "0142-9612",

}

RIS - Lataa

TY - JOUR

T1 - In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells

AU - Figueiredo, Patrícia

AU - Lintinen, Kalle

AU - Kiriazis, Alexandros

AU - Hynninen, Ville

AU - Liu, Zehua

AU - Bauleth-Ramos, Tomás

AU - Rahikkala, Antti

AU - Correia, Alexandra

AU - Kohout, Tomáš

AU - Sarmento, Bruno

AU - Yli-Kauhaluoma, Jari

AU - Hirvonen, Jouni

AU - Ikkala, Olli

AU - Kostiainen, Mauri A.

AU - Santos, Hélder A.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Currently, nanosystems have been developed and applied as promising vehicles for different biomedical applications. We have developed three lignin nanoparticles (LNPs): pure lignin nanoparticles (pLNPs), iron(III)-complexed lignin nanoparticles (Fe-LNPs), and Fe3O4-infused lignin nanoparticles (Fe3O4-LNPs) with round shape, narrow size distribution, reduced polydispersity and good stability at pH 7.4. The LNPs showed low cytotoxicity in all the tested cell lines and hemolytic rates below 12% after 12 h of incubation. Additionally, they induced hydrogen peroxide production in a small extent and time-dependent manner, and the interaction with the cells increased over time, exhibiting a dose-dependent cell uptake. Concerning the drug loading, pLNPs showed the capacity to efficiently load poorly water-soluble drugs and other cytotoxic agents, e.g. sorafenib and benzazulene (BZL), and improve their release profiles at pH 5.5 and 7.4 in a sustained manner. Furthermore, the BZL-pLNPs presented an enhanced antiproliferation effect in different cells compared to the pure BZL and showed a maximal inhibitory concentration ranging from 0.64 to 12.4 μM after 24 h incubation. Overall, LNPs are promising candidates for drug delivery applications, and the superparamagnetic behavior of Fe3O4-LNPs makes them promising for cancer therapy and diagnosis, such as magnetic targeting and magnetic resonance imaging.

AB - Currently, nanosystems have been developed and applied as promising vehicles for different biomedical applications. We have developed three lignin nanoparticles (LNPs): pure lignin nanoparticles (pLNPs), iron(III)-complexed lignin nanoparticles (Fe-LNPs), and Fe3O4-infused lignin nanoparticles (Fe3O4-LNPs) with round shape, narrow size distribution, reduced polydispersity and good stability at pH 7.4. The LNPs showed low cytotoxicity in all the tested cell lines and hemolytic rates below 12% after 12 h of incubation. Additionally, they induced hydrogen peroxide production in a small extent and time-dependent manner, and the interaction with the cells increased over time, exhibiting a dose-dependent cell uptake. Concerning the drug loading, pLNPs showed the capacity to efficiently load poorly water-soluble drugs and other cytotoxic agents, e.g. sorafenib and benzazulene (BZL), and improve their release profiles at pH 5.5 and 7.4 in a sustained manner. Furthermore, the BZL-pLNPs presented an enhanced antiproliferation effect in different cells compared to the pure BZL and showed a maximal inhibitory concentration ranging from 0.64 to 12.4 μM after 24 h incubation. Overall, LNPs are promising candidates for drug delivery applications, and the superparamagnetic behavior of Fe3O4-LNPs makes them promising for cancer therapy and diagnosis, such as magnetic targeting and magnetic resonance imaging.

KW - Antiproliferation effect

KW - Benzazulene

KW - Biocompatibility

KW - Cellular uptake

KW - Drug loading

KW - Lignin nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=85008601977&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2016.12.034

DO - 10.1016/j.biomaterials.2016.12.034

M3 - Article

AN - SCOPUS:85008601977

VL - 121

SP - 97

EP - 108

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

ER -

ID: 10514292