In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination

Claudia Pigliacelli, Kavitha Buntara Sanjeeva, Nonappa, Andrea Pizzi, Alessandro Gori, Francesca Baldelli Bombelli, Pierangelo Metrangolo

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

10 Sitaatiot (Scopus)
146 Lataukset (Pure)

Abstrakti

Peptide-mediated routes to the synthesis of plasmonic nanoparticles have been drawing increasing attention for the development of chiroptically active nanoscale architectures. However, designing a multifunctional peptide able to drive the formation of structurally defined nanomaterials endowed with specific functionalities is still challenging. In this work, iodination has been devised as a strategy to strengthen Au-reduction capability of the amyloidogenic peptide DFNKF and combine it with its distinctive self-assembly features. Thanks to the Au-mediated C - I activation on the phenylalanine iodobenzenes, the peptides yield efficient Au-reduction ability promoting the synthesis of Au nanoparticles, and simultaneously working as templates for their spontaneous self-assembly into spherical superstructures endowed with chiroptical activities. The reaction occurs in situ through a one-pot process in aqueous media. The generality of this approach has been demonstrated using an iodinated derivative of the peptide KLVFF, which also showed reducing and templating abilities forming chiroptically active helical superstructures decorated with Au nanoparticles.

AlkuperäiskieliEnglanti
Sivut2158–2166
Sivumäärä9
JulkaisuACS Nano
Vuosikerta13
Numero2
Varhainen verkossa julkaisun päivämäärä10 tammikuuta 2019
DOI - pysyväislinkit
TilaJulkaistu - 10 tammikuuta 2019
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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  • Projektit

    • 1 Päättynyt

    HYBER: Suomen Akatemian Biosynteettisten hybridimateriaalien molekyylimuokkauksen huippuyksikkö (2014-2019)

    Cherian, T., Nonappa, N., Ikkala, O., Bertula, K., Poutanen, M., Morits, M., Hynninen, V., Myllymäki, T., Toivonen, M., Sohrabi, F., Haataja, J., Sanchez Sanchez, A. & Rissanen, S.

    01/01/201730/06/2020

    Projekti: Academy of Finland: Other research funding

    Laitteet

    OtaNano

    Anna Rissanen (Manager)

    Aalto-yliopisto

    Laitteistot/tilat: Facility

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