In situ cross-linking of stimuli-responsive hemicellulose microgels during spray drying

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Tutkijat

  • Weifeng Zhao
  • Robertus Nugroho

  • Karin Odelius
  • Ulrica Edlund
  • Changsheng Zhao
  • Ann Christine Albertsson

Organisaatiot

  • Sichuan University
  • KTH Royal Institute of Technology

Kuvaus

Chemical cross-linking during spray drying offers the potential for green fabrication of microgels with a rapid stimuli response and good blood compatibility and provides a platform for stimuli-responsive hemicellulose microgels (SRHMGs). The cross-linking reaction occurs rapidly in situ at elevated temperature during spray drying, enabling the production of microgels in a large scale within a few minutes. The SRHMGs with an average size range of ∼1-4 Μm contain O-acetyl-galactoglucomannan as a matrix and poly(acrylic acid), aniline pentamer (AP), and iron as functional additives, which are responsive to external changes in pH, electrochemical stimuli, magnetic field, or dual-stimuli. The surface morphologies, chemical compositions, charge, pH, and mechanical properties of these smart microgels were evaluated using scanning electron microscopy, IR, zeta potential measurements, pH evaluation, and quantitative nanomechanical mapping, respectively. Different oxidation states were observed when AP was introduced, as confirmed by UV spectroscopy and cyclic voltammetry. Systematic blood compatibility evaluations revealed that the SRHMGs have good blood compatibility. This bottom-up strategy to synthesize SRHMGs enables a new route to the production of smart microgels for biomedical applications.

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut4202-4215
Sivumäärä14
JulkaisuACS Applied Materials and Interfaces
Vuosikerta7
Numero7
TilaJulkaistu - 25 helmikuuta 2015
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

ID: 11777249