Impact of physiological noise in characterizing the functional MRI default-mode network in Alzheimer’s disease

Yi Tien Li, Chun Yuan Chang, Yi Cheng Hsu, Jong Ling Fuh, Wen Jui Kuo, Jhy Neng Tasso Yeh, Fa Hsuan Lin*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

7 Sitaatiot (Scopus)

Abstrakti

The functional connectivity of the default-mode network (DMN) monitored by functional magnetic resonance imaging (fMRI) in Alzheimer's disease (AD) patients has been found weaker than that in healthy participants. Since breathing and heart beating can cause fluctuations in the fMRI signal, these physiological activities may affect the fMRI data differently between AD patients and healthy participants. We collected resting-state fMRI data from AD patients and age-matched healthy participants. With concurrent cardiac and respiratory recordings, we estimated both physiological responses phase-locked and non-phase-locked to heart beating and breathing. We found that the cardiac and respiratory physiological responses in AD patients were 3.00 ± 0.51 s and 3.96 ± 0.52 s later (both p < 0.0001) than those in healthy participants, respectively. After correcting the physiological noise in the resting-state fMRI data by population-specific physiological response functions, the DMN estimated by seed-correlation was more localized to the seed region. The DMN difference between AD patients and healthy controls became insignificant after suppressing physiological noise. Our results indicate the importance of controlling physiological noise in the resting-state fMRI analysis to obtain clinically related characterizations in AD.

AlkuperäiskieliEnglanti
ArtikkeliARTN 0271678X19897442
Sivut166-181
Sivumäärä16
JulkaisuJOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Vuosikerta41
Numero1
Varhainen verkossa julkaisun päivämäärä1 tammik. 2020
DOI - pysyväislinkit
TilaJulkaistu - tammik. 2021
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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