Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Nelli Heikkila; Reetta Vanhanen; Dawit A. Yohannes; Paivi Saavalainen; Seppo Meri; T. Sakari Jokiranta; Hanna Jarva; Ilkka P. Mattila; David Hamm; Silja Sormunen; Jari Saramaki; T. Petteri Arstila

doi:10.1002/eji.201948404

Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Nelli Heikkila^*
, Reetta Vanhanen
, Dawit A. Yohannes
, Paivi Saavalainen
, Seppo Meri
, T. Sakari Jokiranta
, Hanna Jarva
, Ilkka P. Mattila
, David Hamm
, Silja Sormunen
, Jari Saramaki
, T. Petteri Arstila

^*Tämän työn vastaava kirjoittaja

University of Helsinki
Adaptive Biotechnologies

Tutkimustuotos: Lehtiartikkeli › Letter › Scientific

8 Sitaatiot (Scopus)

Abstrakti

We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.

Alkuperäiskieli	Englanti
Sivut	748-751
Sivumäärä	4
Julkaisu	European Journal of Immunology
Vuosikerta	50
Numero	5
Varhainen verkossa julkaisun päivämäärä	14 tammik. 2020
DOI - pysyväislinkit	https://doi.org/10.1002/eji.201948404
Tila	Julkaistu - 1 toukok. 2020
OKM-julkaisutyyppi	B1 Kirjoitus tieteellisessä aikakauslehdessä

Rahoitus

We thank Tamas Bazsinka from University of Helsinki for expert technical assistance, and the families who participated in the study. The study has been funded by the University of Helsinki Research Foundation, Emil Aaltonen Foundation, Biomedicum Helsinki Foundation and M.D. Ph.D. program of the University of Helsinki

Pääsy asiakirjaan

10.1002/eji.201948404

http://hdl.handle.net/10138/323639

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Link to publication in Scopus

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Hakala, M. (Manager)
Perustieteiden korkeakoulu
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title = "Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins",

abstract = "We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.",

keywords = "CDR3, genetics, TCR repertoire, thymic selection, twins, DIVERSITY",

author = "Nelli Heikkila and Reetta Vanhanen and Yohannes, \{Dawit A.\} and Paivi Saavalainen and Seppo Meri and Jokiranta, \{T. Sakari\} and Hanna Jarva and Mattila, \{Ilkka P.\} and David Hamm and Silja Sormunen and Jari Saramaki and Arstila, \{T. Petteri\}",

year = "2020",

month = may,

day = "1",

doi = "10.1002/eji.201948404",

language = "English",

volume = "50",

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journal = "European Journal of Immunology",

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TY - JOUR

T1 - Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

AU - Heikkila, Nelli

AU - Vanhanen, Reetta

AU - Yohannes, Dawit A.

AU - Saavalainen, Paivi

AU - Meri, Seppo

AU - Jokiranta, T. Sakari

AU - Jarva, Hanna

AU - Mattila, Ilkka P.

AU - Hamm, David

AU - Sormunen, Silja

AU - Saramaki, Jari

AU - Arstila, T. Petteri

PY - 2020/5/1

Y1 - 2020/5/1

N2 - We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.

AB - We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.

KW - CDR3

KW - genetics

KW - TCR repertoire

KW - thymic selection

KW - twins

KW - DIVERSITY

UR - https://www.scopus.com/pages/publications/85078028365

U2 - 10.1002/eji.201948404

DO - 10.1002/eji.201948404

M3 - Letter

C2 - 31872865

SN - 0014-2980

VL - 50

SP - 748

EP - 751

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 5

ER -

Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

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