TY - JOUR
T1 - Hippocampus-Centered Network Is Associated With Positive Symptom Alleviation in Patients With First-Episode Psychosis
AU - Alho, Jussi
AU - Lahnakoski, Juha M.
AU - Panula, Jonatan M.
AU - Rikandi, Eva
AU - Mäntylä, Teemu
AU - Lindgren, Maija
AU - Kieseppä, Tuula
AU - Suvisaari, Jaana
AU - Sams, Mikko
AU - Raij, Tuukka T.
N1 - Funding Information:
This work was supported by the Sigrid Jusélius Foundation (to JS and TTR), the Finnish Cultural Foundation (to JML and JS), the Academy of Finland (Grant Nos. 278171 and 323035 [to JS] and Grant No. 315861 [to TTR]), the Finnish Medical Foundation (to JMP and TTR), the Medical Society of Finland (to JMP), state funding for university-level health research (Hospital District of Helsinki and Uusimaa, Grant Nos. TYH2013332, TYH2014228, and TYH2017128 [to TK]), and the European Union's Seventh Framework Programme for project METSY (Grant No. 602478 [to JS]). We thank the study participants and Laura Hietapakka, Marita Kattelus, Sanna Leppänen, Tuula Mononen, Minna Holm, and Marjut Grainger for their contribution to data collection. The authors report no biomedical financial interests or potential conflicts of interest.
Funding Information:
This work was supported by the Sigrid Jusélius Foundation (to JS and TTR), the Finnish Cultural Foundation (to JML and JS), the Academy of Finland (Grant Nos. 278171 and 323035 [to JS] and Grant No. 315861 [to TTR]), the Finnish Medical Foundation (to JMP and TTR), the Medical Society of Finland (to JMP), state funding for university-level health research (Hospital District of Helsinki and Uusimaa, Grant Nos. TYH2013332, TYH2014228, and TYH2017128 [to TK]), and the European Union’s Seventh Framework Programme for project METSY (Grant No. 602478 [to JS]).
Publisher Copyright:
© 2023 Society of Biological Psychiatry
PY - 2023/12
Y1 - 2023/12
N2 - Background: Previous functional magnetic resonance imaging studies have reported widespread brain functional connectivity alterations in patients with psychosis. These studies have mostly used either resting-state or simple-task paradigms, thereby compromising experimental control or ecological validity, respectively. Additionally, in a conventional functional magnetic resonance imaging intrasubject functional connectivity analysis, it is difficult to identify which connections relate to extrinsic (stimulus-induced) and which connections relate to intrinsic (non–stimulus-related) neural processes. Methods: To mitigate these limitations, we used intersubject functional connectivity (ISFC) to analyze longitudinal functional magnetic resonance imaging data collected while 36 individuals with first-episode psychosis (FEP) and 29 age- and sex-matched population control participants watched scenes from the fantasy movie Alice in Wonderland at baseline and again at 1-year follow-up. Furthermore, to allow unconfounded comparison and to overcome possible circularity of ISFC, we introduced a novel approach wherein ISFC in both the FEP and population control groups was calculated with respect to an independent group of participants (not included in the analyses). Results: Using this independent-reference ISFC approach, we found an interaction effect wherein the independent-reference ISFC in individuals with FEP, but not in the control group participants, was significantly stronger at baseline than at follow-up in a network centered in the hippocampus and involving thalamic, striatal, and cortical regions, such as the orbitofrontal cortex. Alleviation of positive symptoms, particularly delusions, from baseline to follow-up was correlated with decreased network connectivity in patients with FEP. Conclusions: These findings link deviation of naturalistic information processing in the hippocampus-centered network to positive symptoms.
AB - Background: Previous functional magnetic resonance imaging studies have reported widespread brain functional connectivity alterations in patients with psychosis. These studies have mostly used either resting-state or simple-task paradigms, thereby compromising experimental control or ecological validity, respectively. Additionally, in a conventional functional magnetic resonance imaging intrasubject functional connectivity analysis, it is difficult to identify which connections relate to extrinsic (stimulus-induced) and which connections relate to intrinsic (non–stimulus-related) neural processes. Methods: To mitigate these limitations, we used intersubject functional connectivity (ISFC) to analyze longitudinal functional magnetic resonance imaging data collected while 36 individuals with first-episode psychosis (FEP) and 29 age- and sex-matched population control participants watched scenes from the fantasy movie Alice in Wonderland at baseline and again at 1-year follow-up. Furthermore, to allow unconfounded comparison and to overcome possible circularity of ISFC, we introduced a novel approach wherein ISFC in both the FEP and population control groups was calculated with respect to an independent group of participants (not included in the analyses). Results: Using this independent-reference ISFC approach, we found an interaction effect wherein the independent-reference ISFC in individuals with FEP, but not in the control group participants, was significantly stronger at baseline than at follow-up in a network centered in the hippocampus and involving thalamic, striatal, and cortical regions, such as the orbitofrontal cortex. Alleviation of positive symptoms, particularly delusions, from baseline to follow-up was correlated with decreased network connectivity in patients with FEP. Conclusions: These findings link deviation of naturalistic information processing in the hippocampus-centered network to positive symptoms.
KW - Functional connectivity
KW - Functional magnetic resonance imaging (fMRI)
KW - Hippocampus
KW - Movie
KW - Positive symptoms
KW - Psychosis
UR - http://www.scopus.com/inward/record.url?scp=85172286745&partnerID=8YFLogxK
U2 - 10.1016/j.bpsc.2023.06.002
DO - 10.1016/j.bpsc.2023.06.002
M3 - Article
C2 - 37336263
AN - SCOPUS:85172286745
SN - 2451-9022
VL - 8
SP - 1197
EP - 1206
JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
IS - 12
ER -