Group-level and functional-region analysis of electric-field shape during cerebellar transcranial direct current stimulation with different electrode montages

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Group-level and functional-region analysis of electric-field shape during cerebellar transcranial direct current stimulation with different electrode montages. / Gomez-Tames, Jose; Asai, Akihiro; Mikkonen, Marko; Laakso, Ilkka; Tanaka, Satoshi; Uehara, Shintaro; Otaka, Yohei; Hirata, Akimasa.

julkaisussa: JOURNAL OF NEURAL ENGINEERING, Vuosikerta 16, Nro 3, 036001, 06.2019.

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

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Gomez-Tames, Jose ; Asai, Akihiro ; Mikkonen, Marko ; Laakso, Ilkka ; Tanaka, Satoshi ; Uehara, Shintaro ; Otaka, Yohei ; Hirata, Akimasa. / Group-level and functional-region analysis of electric-field shape during cerebellar transcranial direct current stimulation with different electrode montages. Julkaisussa: JOURNAL OF NEURAL ENGINEERING. 2019 ; Vuosikerta 16, Nro 3.

Bibtex - Lataa

@article{01d7aaba42e44854bfe1e76f8bd8829f,
title = "Group-level and functional-region analysis of electric-field shape during cerebellar transcranial direct current stimulation with different electrode montages",
abstract = "Objective. Cerebellar transcranial direct current stimulation (ctDCS) is a neuromodulation scheme that delivers a small current to the cerebellum. In this work, we computationally investigate the distributions and strength of the stimulation dosage during ctDCS with the aim of determining the targeted cerebellar regions of a group of subjects with different electrode montages. Approach. We used a new inter-individual registration method that permitted the projection of computed electric fields (EFs) from individual realistic head models (n = 18) to standard cerebellar template for the first time. Main results. Variations of the EF on the cerebellar surface were found to have standard deviations of up to 55{\%} of the mean. The dominant factor that accounted for 62{\%} of the variability of the maximum EFs was the skin- cerebellum distance, whereas the cerebrospinal fluid volume explained 53{\%} of the average EF distribution. Despite the inter-individual variations, a systematic tendency of the EF hotspot emerges beneath the active electrode in group-level analysis. The hotspot can be adjusted by the electrode position so that the most effective stimulation is delivered to a group of subjects. Significance. Targeting specific cerebellar structures with ctDCS is not straightforward, as neuromodulation depends not only on the placement/design of the electrodes configuration but also on inter-individual variability due to anatomical differences. The proposed method permitted generalizing the EFs to a cerebellum atlas. The atlas is useful for studying the mechanisms of ctDCS, planning ctDCS and explaining findings of experimental studies.",
keywords = "Cerebellar transcranial direct current stimulation, Cerebellum, Inter-subject variability, Functional network, Computational model, Electric field, DC stimulation, Motor, Organization, Cortex, TDCS, Localization, Variability, Anisotroy, Impedance, Muscle",
author = "Jose Gomez-Tames and Akihiro Asai and Marko Mikkonen and Ilkka Laakso and Satoshi Tanaka and Shintaro Uehara and Yohei Otaka and Akimasa Hirata",
year = "2019",
month = "6",
doi = "10.1088/1741-2552/ab0ac5",
language = "English",
volume = "16",
journal = "JOURNAL OF NEURAL ENGINEERING",
issn = "1741-2560",
number = "3",

}

RIS - Lataa

TY - JOUR

T1 - Group-level and functional-region analysis of electric-field shape during cerebellar transcranial direct current stimulation with different electrode montages

AU - Gomez-Tames, Jose

AU - Asai, Akihiro

AU - Mikkonen, Marko

AU - Laakso, Ilkka

AU - Tanaka, Satoshi

AU - Uehara, Shintaro

AU - Otaka, Yohei

AU - Hirata, Akimasa

PY - 2019/6

Y1 - 2019/6

N2 - Objective. Cerebellar transcranial direct current stimulation (ctDCS) is a neuromodulation scheme that delivers a small current to the cerebellum. In this work, we computationally investigate the distributions and strength of the stimulation dosage during ctDCS with the aim of determining the targeted cerebellar regions of a group of subjects with different electrode montages. Approach. We used a new inter-individual registration method that permitted the projection of computed electric fields (EFs) from individual realistic head models (n = 18) to standard cerebellar template for the first time. Main results. Variations of the EF on the cerebellar surface were found to have standard deviations of up to 55% of the mean. The dominant factor that accounted for 62% of the variability of the maximum EFs was the skin- cerebellum distance, whereas the cerebrospinal fluid volume explained 53% of the average EF distribution. Despite the inter-individual variations, a systematic tendency of the EF hotspot emerges beneath the active electrode in group-level analysis. The hotspot can be adjusted by the electrode position so that the most effective stimulation is delivered to a group of subjects. Significance. Targeting specific cerebellar structures with ctDCS is not straightforward, as neuromodulation depends not only on the placement/design of the electrodes configuration but also on inter-individual variability due to anatomical differences. The proposed method permitted generalizing the EFs to a cerebellum atlas. The atlas is useful for studying the mechanisms of ctDCS, planning ctDCS and explaining findings of experimental studies.

AB - Objective. Cerebellar transcranial direct current stimulation (ctDCS) is a neuromodulation scheme that delivers a small current to the cerebellum. In this work, we computationally investigate the distributions and strength of the stimulation dosage during ctDCS with the aim of determining the targeted cerebellar regions of a group of subjects with different electrode montages. Approach. We used a new inter-individual registration method that permitted the projection of computed electric fields (EFs) from individual realistic head models (n = 18) to standard cerebellar template for the first time. Main results. Variations of the EF on the cerebellar surface were found to have standard deviations of up to 55% of the mean. The dominant factor that accounted for 62% of the variability of the maximum EFs was the skin- cerebellum distance, whereas the cerebrospinal fluid volume explained 53% of the average EF distribution. Despite the inter-individual variations, a systematic tendency of the EF hotspot emerges beneath the active electrode in group-level analysis. The hotspot can be adjusted by the electrode position so that the most effective stimulation is delivered to a group of subjects. Significance. Targeting specific cerebellar structures with ctDCS is not straightforward, as neuromodulation depends not only on the placement/design of the electrodes configuration but also on inter-individual variability due to anatomical differences. The proposed method permitted generalizing the EFs to a cerebellum atlas. The atlas is useful for studying the mechanisms of ctDCS, planning ctDCS and explaining findings of experimental studies.

KW - Cerebellar transcranial direct current stimulation

KW - Cerebellum

KW - Inter-subject variability

KW - Functional network

KW - Computational model

KW - Electric field

KW - DC stimulation

KW - Motor

KW - Organization

KW - Cortex

KW - TDCS

KW - Localization

KW - Variability

KW - Anisotroy

KW - Impedance

KW - Muscle

U2 - 10.1088/1741-2552/ab0ac5

DO - 10.1088/1741-2552/ab0ac5

M3 - Article

VL - 16

JO - JOURNAL OF NEURAL ENGINEERING

JF - JOURNAL OF NEURAL ENGINEERING

SN - 1741-2560

IS - 3

M1 - 036001

ER -

ID: 32863811