Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

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Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs. / Figueiredo, Patrícia; Ferro, Cláudio; Kemell, Marianna; Liu, Zehua; Kiriazis, Alexandros; Lintinen, Kalle; Florindo, Helena F.; Yli-Kauhaluoma, Jari; Hirvonen, Jouni; Kostiainen, Mauri A.; Santos, Hélder A.

julkaisussa: Nanomedicine, Vuosikerta 12, Nro 21, 01.11.2017, s. 2581-2596.

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Harvard

Figueiredo, P, Ferro, C, Kemell, M, Liu, Z, Kiriazis, A, Lintinen, K, Florindo, HF, Yli-Kauhaluoma, J, Hirvonen, J, Kostiainen, MA & Santos, HA 2017, 'Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs', Nanomedicine, Vuosikerta. 12, Nro 21, Sivut 2581-2596. https://doi.org/10.2217/nnm-2017-0219

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Author

Figueiredo, Patrícia ; Ferro, Cláudio ; Kemell, Marianna ; Liu, Zehua ; Kiriazis, Alexandros ; Lintinen, Kalle ; Florindo, Helena F. ; Yli-Kauhaluoma, Jari ; Hirvonen, Jouni ; Kostiainen, Mauri A. ; Santos, Hélder A. / Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs. Julkaisussa: Nanomedicine. 2017 ; Vuosikerta 12, Nro 21. Sivut 2581-2596.

Bibtex - Lataa

@article{00a06875e0c34ba3b2265dc1156287bc,
title = "Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs",
abstract = "Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.",
keywords = "antiproliferative effect, benzazulene, carboxylated lignin nanoparticles, drug loading, pH-responsive release, targeting functionalization",
author = "Patr{\'i}cia Figueiredo and Cl{\'a}udio Ferro and Marianna Kemell and Zehua Liu and Alexandros Kiriazis and Kalle Lintinen and Florindo, {Helena F.} and Jari Yli-Kauhaluoma and Jouni Hirvonen and Kostiainen, {Mauri A.} and Santos, {H{\'e}lder A.}",
year = "2017",
month = "11",
day = "1",
doi = "10.2217/nnm-2017-0219",
language = "English",
volume = "12",
pages = "2581--2596",
journal = "Nanomedicine",
issn = "1743-5889",
publisher = "Future Medicine Ltd.",
number = "21",

}

RIS - Lataa

TY - JOUR

T1 - Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

AU - Figueiredo, Patrícia

AU - Ferro, Cláudio

AU - Kemell, Marianna

AU - Liu, Zehua

AU - Kiriazis, Alexandros

AU - Lintinen, Kalle

AU - Florindo, Helena F.

AU - Yli-Kauhaluoma, Jari

AU - Hirvonen, Jouni

AU - Kostiainen, Mauri A.

AU - Santos, Hélder A.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.

AB - Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.

KW - antiproliferative effect

KW - benzazulene

KW - carboxylated lignin nanoparticles

KW - drug loading

KW - pH-responsive release

KW - targeting functionalization

UR - http://www.scopus.com/inward/record.url?scp=85032441481&partnerID=8YFLogxK

U2 - 10.2217/nnm-2017-0219

DO - 10.2217/nnm-2017-0219

M3 - Article

AN - SCOPUS:85032441481

VL - 12

SP - 2581

EP - 2596

JO - Nanomedicine

JF - Nanomedicine

SN - 1743-5889

IS - 21

ER -

ID: 16230288