Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

Patrícia Figueiredo*, Cláudio Ferro, Marianna Kemell, Zehua Liu, Alexandros Kiriazis, Kalle Lintinen, Helena F. Florindo, Jari Yli-Kauhaluoma, Jouni Hirvonen, Mauri A. Kostiainen, Hélder A. Santos

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

27 Sitaatiot (Scopus)

Abstrakti

Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.

AlkuperäiskieliEnglanti
Sivut2581-2596
Sivumäärä16
JulkaisuNanomedicine
Vuosikerta12
Numero21
DOI - pysyväislinkit
TilaJulkaistu - 1 marraskuuta 2017
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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