From jamming to collective cell migration through a boundary induced transition

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Tutkijat

  • Oleksandr Chepizhko
  • Maria Chiara Lionetti
  • Chiara Malinverno
  • Costanza Giampietro
  • Giorgio Scita
  • Stefano Zapperi
  • Caterina A.M. La Porta

Organisaatiot

  • Innsbruck Medical University
  • University of Milano
  • Swiss Federal Institute of Technology Zurich
  • Center for Complexity and Biosystems
  • CNR-ENEA-EURATOM Association

Kuvaus

Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut3774-3782
Sivumäärä9
JulkaisuSoft Matter
Vuosikerta14
Numero19
TilaJulkaistu - 1 tammikuuta 2018
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

ID: 21779198